探针靶位点:CRLF2/IGH 供货周期:两周 管理类别:待界定 产品概况 Ph-like ALL BCR-ABL1-like ALL(Ph-like ALL)与预后差相关(5年DFS为60%),在儿童B细胞ALL中较为少见,约为3%;但在成人ALL中为最常见的亚型,约为25%。Ph-like ALL发病率与年龄增长呈正相关。90%Ph-like ALL可见激酶活化异常,如ABL1、...
CRLF2/IGH融合基因t(X;14)/t(Y;14)探针试剂(荧光原位杂交法)-探针-广州安必平医药科技股份有限公司(股票代码:688393)专注于肿瘤筛查与诊断,自主研发了一系列肿瘤筛查及诊断试剂与配套设备,主要应用科室为病理科。目前已搭建液基细胞学(LBP)、聚合酶链式反应(PCR
Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH- CRLF2and JAK2 mutations, persistence of minimal residual disease and poor prognosis. Haematologica. 2017 Jan;102(1):130-8.Philadelphia chromosome-like acute lymphoblastic leukemia in adults have frequent IGHCRLF2 ...
CRLF2 rearrangement places full-length CRLF2 under alternate transcriptional control and can result from either an intrachromosomal CRLF2-P2RY8 deletion or a CRLF2-IGH translocation. All of the reported CRLF2-P2RY8 deletions involve V(D)J-type breaks at highly localized heptamer sequences upstream...
Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparityCancer geneticsOncogenesRisk factorsdoi:10.1038/s41375-021-01133-4Gordana RacaHisham Abdel-AzimFeng YueJames Broach...
Subsequently we have identified 4 B-ALL cases with cryptic CRLF2-IGH translocations that would otherwise have gone undetected. Detection of genetic alterations in B-ALL, such as CRLF2 rearrangements, may enhance patient risk stratification and therapy options in pediatric B-ALL....