Application scope : Pathology Hematology Chromosome Prenatal CCND1/IGH Dual Color Dual Fusion ProbeCat.No.: DF035 Chromosome Region: 11q13/14q32 Inquiry Product overview IGH, 14q32, Green CCND1, 11q13, Orange Copyright © 2014-2025 Diaglogic Biolabs (Xiamen) Co., Ltd....
CCND1-IGH gene fusion-amplificationMYC copy number gainCD5 negativePleomorphic variantObjectives: Mantle cell lymphoma (MCL) may present de novo or undergo progression to a clinically aggressive variant, known as a blastoid or pleomorphic variant. We report an unusual case of classic MCL in a 78...
CCND1-IGHFusion-Amplification andMYCCopy Number Gain in a Case of Pleomorphic Variant Mantle Cell Lymphoma Mantle cell lymphoma (MCL) may present de novo or undergo progression to a clinically aggressive variant, known as a blastoid or pleomorphic variant. We re... Y Miao,P Lin,W Wang,.....
Initial conventional cytogenetic analysis showed a complex karyotype with amplification of the CCND1-IGH fusion gene on the der(14): 44, Y, t(X;2)(p22.3;q21), del(2)(p21), del(6)(p23), add(7)(p22),-9, del(9)(p22), add(11)(q13),-13, add(14)(p11.2), der(14)t(11;...
Cell 135, 1028–1038, December 12, 2008 [3] K. Yamamoto, K. Yakushijin and M. Ito et al.MYC amplification on double minute chromosomes in plasma cell leukemia with double IGH/CCND1 fusion genes. Cancer Genetics 242 (2020) 35–40上一篇:CCND1断裂基因检测探针 下一篇:ATM基因缺失检测探针 ...
Our current Multiple Myeloma panel (MMP) is designed as a reflex test, where positive IGH break-apart (IGH-BAP) and negative t(11;14)/IGH-CCND1 fusion patterns direct subsequent testing for t(4;14)/IGH-FGFR3 and t(14;16)/IGH-MAF fusions. Included in the first tier panel are probes...
血液肿瘤如多发性骨髓瘤(MM)是浆细胞克隆性增殖的恶性肿瘤,已经证实14号染色体免疫球蛋白编码基因(IGH)重排是MM结构异常中最常见的重排,其目前主要包括CCND1、BCL2、FGFR3、MAFB等不同亚型。 传统的检测IGH重排的方案例如包括:基于FISH(荧光原位杂交)的重排检测方法和基于NGS(二代测序)数据的重排检测方法。其中基于...
g. in t(11;14)/CCND1-IGH -positive mantle cell lymphoma, occur predominantly near CpG dinucleotides, and to a lesser extent near the (A/T)GC(A/T) consensus motif (Greisman et al., 2012). Chromosomal breaks at a germinal center B-cell stage, e.g. with t(8;14)/MYC-IGH, were...
The t(11;14)(q13;q32) involving 1GH and CCND1 and Peter,M.,Lee,... - 《Journal of the Association of Genetic Technologists》 被引量: 0发表: 2016年 Recurrent involvement of ring-type zinc finger genes in complex molecular rearrangements in childhood acute myelogeneous leukemia with transloc...
fusion translocation probes or with generic dual-colorMYC“split” probes (Figure 39.8). Thekaryotypesin adults and children with BL exhibit a core set of aberrations (a cytogenetic detection of an IGH@/MYC translocation andabsenceof translocations ofBCL2,BCL6, and/orCCND1) and with minor ...