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IgG4相关疾病(IgG4-related disease,IgG4-RD)是一种免疫介导的与纤维炎性损伤有关的疾病,几乎可以发生在任何解剖部位。它通常表现为多器官损伤,可能与恶性肿瘤、感染或其他免疫介导的疾病相混淆,如干燥综合征、ANCA(antineutrophil cytoplasmic antibody,抗中性粒细胞胞浆抗体)相关性血管炎。对该病患者的评估往往...
少数IgG4-ROD单纯累及眼部,更多情况下它是全身疾病的一部分[ 3 ],称为IgG4相关性疾病(immunoglobulin-G4 related disease,IgG4-RD),可累及胰腺、胆道、腹膜后、肾脏、垂体、硬脑膜和冠状动脉等,严重者可危及生命,因此,IgG4-ROD患者的全身筛查极为重要...
2. Stone JH, Khosroshahi A, Hilgenberg A, et al: IgG4-related systemic disease and lymphoplasmacytic aortitis.Arthritis Rheum2009,60:3139-3145. 3. Dahlgren M, Khosroshahi A, Nielsen GP, et al: Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic diseas...
参考文献: Wallace ZS, Naden RP, Chari S, et al. The 2019 American College of Rheumatology/European League Against Rheumatism classification criteria for IgG4-related disease. Ann Rheum Dis. 2020 ;79(1):77-87. 点击公众号主界面右...
[2]Matsui S, Yamamoto H, Minamoto S, Waseda Y,Mishima M, Kubo K. Proposed diagnostic criteria for IgG4-related respiratorydisease. Respir Investig. 2016 Mar;54(2):130-2. doi:10.1016/j.resinv.2015.09.002. Epub 2015 Oct 20. PMID:...
IgG4相关眼病(immunoglobulin-G4 related ophthalmic disease,IgG4-ROD)是一种眼部由免疫介导的慢性炎症伴纤维化性的疾病,主要组织病理表现为IgG4 +浆细胞浸润,并伴有席纹状纤维化、闭塞性静脉炎和嗜酸性粒细胞浸润。显著升高的血清IgG4水平和肿块样病变是该病最常见的临床表现 [ 1 ] 。IgG4-ROD可累及多种眼部组...