1.2.2 鉴别诊断目前在临床上,有部分肝移植后出现丰富IgG4阳性浆细胞浸润的肝损伤病例被报道。 在同种异体肝移植中,由于富含浆细胞浸润所致肝损伤被称为新发的“自身免疫性”肝炎或浆细胞肝炎(plasma cell hepatitis,PCH),罗碧芬等检索相关PCH的文献发现,PCH...
[9]Chang SY, Keogh KA, Lewis JE, et al. IgG4-positive plasma cells in granulomatosis with polyangiitis(Wegener's): a clinicopathologic and immunohistochemical study on 43 granulomatosis with polyangiitis and 20 control cases...
图2 十二指肠溃疡活检组织免疫组化可见多量IgG4阳性浆细胞浸润 Figure 2 Immunohistochemical staining revealed remarkable infiltration of IgG4-positive plasma cells into duodenal tissue
它包括弓形虫(Toxplasma，Tox)、风疹病毒(nubellavirus，Rv)、巨细胞病毒(Cytomegalo virus，Cmv)、单纯...
7、 T-cells & Cytotxic T-cells,15,资料类,In humoral immunity B-cells recognize soluble or cell surface antigens (on extracellular microbes ) and differentiate into antibody secreting plasma cells. In cell-mediated immunity helper T-cells recognize antigens on the surfaces of antigen-presenting ...
4. Saeki T, Saito A, Hiura T, et al: Lymphoplasmacytic infiltration of multiple organs with immunoreactivity for IgG4: IgG4-related systemic disease.Intern Med2006,45:163-167. 5. Kamisawa T, Takuma K, Egawa N, et al: Autoimmune pancreatitis and IgG4-related sclerosing disease.Nat Rev ...
Upon immune activation, B cells must shift rapidly from a metabolically quiescent state to a high energy-consumption state. This metabolic shift is absolutely required for B cells to rapidly undergo clonal expansion, and differentiate into germinal center B cells (GCBCs) and plasma cells that ...
这一类型的形态学特征也与自身免疫性疾病相关的淋巴结肿大有重叠,如类风湿性关节炎、所谓的特发性浆细胞性淋巴增殖性疾病伴多克隆丙种球蛋白血症(idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia;部分病例可能是IgG4相关硬化性淋巴结肿大)。
7.Salazar E, Kuchipudi SV, Christensen PA, et al. Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma. bioRxiv [Preprint]. 2020 Jun 9:2020.06.08.138990. doi: 10.1101/2020.06.08.138990. ...
Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1, maki...