人胰岛素样生长因子结合蛋白-1(IGFBP-1)是一种234个氨基酸的蛋白质,是以高亲和力结合IGF-I和IGF-II并调节其代谢和促有丝分裂作用的六种循环蛋白家族的成员。 肝脏、卵巢颗粒细胞、蜕膜化子宫内膜和许多其他细胞类型产生天然人IGFBP-1。 IGFBP-1结合IGF-I和IGF-II。 血清IGFBP-1水平通过胰岛素诱导的IGFBP-1产生抑...
FTO exerts functions by regulating its mRNA targets, especially IGFBP2, in an m6A-dependent manner. Regain of Ara-C tolerance is observed when IGFBP2 is overexpressed in FTO-knockdown t(8;21) AML cells. Our work reveals a therapeutic potential of targeting AML1-ETO/FTO/IGFBP2 minicircuitry ...
FTO exerts functions by regulating its mRNA targets, especially IGFBP2, in an m6A-dependent manner. Regain of Ara-C tolerance is observed when IGFBP2 is overexpressed in FTO-knockdown t(8;21) AML cells.Conclusion Our work reveals a therapeutic potential of targeting AML1-ETO/FTO/IGFBP2 mini...