2022 Elsevier Inc.The N6-methyladenosine (m6A) is involved in the regulation of cell proliferation and metastasis formation in multiple cancers. However, the biological significance of RNA m6A reader IGF2BP1 and
PF小鼠肺组织中总m6A修饰水平显著升高,且IGF2BP1在巨噬细胞中特异性高表达,伴随M2型巨噬标志物(Arg1、CCL18、Ym1、CD163)和促纤维化因子(TGF-β1、α-SMA、Col-I/III)的显著上调。
内容提示: http://jmurology.xjtu.edu.cn;zgmnwk.cug.top·基础研究·m6A 阅读蛋白 IGF2BP1 在膀胱癌中的表达及作用周子健,李 凯,蔡令凯,庄俊涛,杨 潇,杨海伟,李鹏超,吕 强(南京医科大学第一附属医院泌尿外科,江苏南京 210029)Theexpressionandroleofm6AreaderIGF2BP1inbladdercancerZHOUZijian,LIKai,CAILingkai...
m6A reader Igf2bp1 regulates the inflammatory responses of Microglia by stabilizing Gbp11 and cp mRNAs. Front Immunol. 2022;13:872252. Article CAS PubMed PubMed Central Google Scholar Dong G, Yu J, Shan G, Su L, Yu N, Yang S. N6-Methyladenosine methyltransferase METTL3 promotes ...
[6,7]. An instance is the demonstrated role of m6A demethylase ALKB homolog 5 (ALKBH5) in promoting NSCLC progression through tissue inhibitor of metalloproteinases 3 (TIMP3) stability regulation [8]. Also, the m6A reader YTH domain family member 2 (YTHDF2) amplifies the proliferation and ...
The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) is a member of the IGF2BP family (including IGF2BP1-3) and is an m6A “reader” protein [13]. IGF2BP1 is believed to promote the proliferation, migration, invasion, and metastasis of tumor cells [14]. Studies have ...
1 The KH domains of IGF2BP1 recognize and bind m6A-mRNAs, as well as the potential fate selection of IGF2BP1-targeted mRNAs. a Domain structure of human IGF2BP1. RNA-binding domains include two RNA recognition motifs (RRMs, blue) and four hnRNP-K homology domains (KH, red) [5]. b ...
In addition, the selective manner may partially result from the competitive combination on m6A-containing mRNAs between IGF2BP1 and other m6A-binding proteins such as YTHDFs. The reasonable inferences about the functions of IGF2BP1 in cancer biology can be confirmed in the future by in vivo and...
今天小编分享一篇2020年4月3日发表于Nature Communications的文章——An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis. N6-甲基腺苷(m6A)是真核RNA中最普遍的修饰。m6A的生物学重要性取决于控制 mRNA 命运和功能的m6A阅读蛋白。然而,m6A阅读蛋白的其他调控亚基是否参与RNA的m6A...
It was known that some co-factors of IGF2BP1, such as the ELAV-like RNA binding protein 1 (ELAVL1), could be recruited by IGF2BP1 to protect m6A-containing mRNAs from degradation.11 Whether the mRNA of LDHA is methylated at m6A resulting in recognition by IGF2BP1 needs to be further ...