Systematic reviews have reported that high normal range circulating levels of total IGF-I predict for pre- but not post-menopausal breast cancer. By contrast, associations with circulating IGFBP-3 have been inconsistent. A cumulative meta-analysis demonstrates that earlier reported positive associations ...
This may reflect aberrations in GH and/or IGF-I actions at the cellular level, and thus this study compared the response of skin fibroblasts from normal children (n = 5) and girls with TS (n = 8) to GH, IGF-I, or a combination, by assessing the IGF binding protein (IGFBP) profile...
It is also possible that in TS, impaired IGF-I action may reflect a reduction in bioavailability because fibroblast cells from children with TS have been shown to produce more IGF binding protein (IGFBP)-3—a negative regulator of IGF function—than fibroblasts from normal chil- dren (10). ...
IGFBP-3 values after hGH remained less than 5th percentile. IGFBP-1 values showed the normal fall with age, some being above the normal range; IGFBP-... MO Savage,WF Blum,MB Ranke,... - 《Journal of Clinical Endocrinology & Metabolism》 被引量: 618发表: 1993年 Serum insulin﹍ike growt...
DNA methylation at the IGF2/H19 locus is a key determinant of the newborn's weight variance within normal range (14). Moreover, fetal IGF2 levels may be modulated by environ- mental insults, including nutrition (15) and maternal metabolism: maternal gestational diabetes (GDM) is a glucose...
Myoblast fusion plays a crucial role in myogenesis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) functions as an RNA N6-methyladenosine reader and exerts important roles in various biological processes. While our prior study suggested Ig
Myoblast fusion plays a crucial role in myogenesis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) functions as an RNA N6-methyladenosine reader and exerts important roles in various biological processes. While our prior study suggested Ig
Protein binding was subsequently detected through Western blotting using the respective antibodies. Chromosome conformation capture (3 C) assays 3C assays coupled with PCR were performed as described previously [20]. Briefly, HCC cells were cross-linked with 2% formaldehyde, and the fixation was ...
action of ncRNAs. Notably, IGFBP-2, IGFBP-3, and IGFBP-5 participate in a wide variety of ncRNA-regulated pathways, with both stimulatory and inhibitory effects on cancer cell functions. This complexity of regulation may offer new avenues for therapeutic intervention in a wide range of ...
action of ncRNAs. Notably, IGFBP-2, IGFBP-3, and IGFBP-5 participate in a wide variety of ncRNA-regulated pathways, with both stimulatory and inhibitory effects on cancer cell functions. This complexity of regulation may offer new avenues for therapeutic intervention in a wide range of ...