The interpretation of growth hormone stimulation testing is dependent on both the peak growth hormone concentration, but also on the baseline IGF-1 Z-score, particularly in cases of partial deficiency. Although, nation wide, Dutch laboratories have harmonized their measurement for IGF-1 (as was ...
Independent variables included in the initial univariate analysis were postmenstrual age at the time of MR scanning (weeks), GA at birth (weeks), development in birth weight standard deviation score from birth until the time of MR scanning, total parenteral and enteral energy intake PND 1–28 (...
The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tissue (aKO) led
This decrease can confound the interpretation of IGFBP-3 levels seen after the 3-h infusion, as the amount of IGFBP-3 infused is not enough to “overcome” the physiologic decrease. This is more apparent with IGFBP-3 since the molar amount of IGFBP-3 infused with IPLEX is less, relative...
ZZ and ZH performed the experiments and analyzed the data. ZZ and WC wrote the manuscript and were responsible for language revisions. SL made substantial contributions to conception and design, acquisition of data, and analysis and interpretation of the data. All the authors have read and approve...
In the present screen, PFKFB3 was identified as a positive regulatory kinase of GLUT4 translocation, as its knockdown impaired IGF-1-stimulated GLUT4 translocation (Figs. 1F, 2B, and 4, Z-score −1.54). To validate this finding in 3T3-L1 adipocytes, we used siRNA to knockdown PFKFB3 mR...
(Eagle v2.3;631000G64Phase 3 v5; Population:ALL). SNPs with a conservative imputation INFO score of >0.7 were retained (INFO score is a measure of confidence in imputed genotype call). For cis e-QTL inference, SNPs within ±500 kb of CpG probes in differentially-methylated regions were...
The immunoreactivity score (IRS) was calculated using the formula: intensity × extent of positivity [27]. 2.13. Statistical analysis All the data represent the mean ± SEM of at least three independent experiments and were analysed for significance using unpaired Student's t-test. p value ≤ ...
This stands to deepen our understanding of tissue-specific and disease- specific signaling networks that are predicated upon the varying and inevitably complex interpretation of the potential interactome by the available expressed interaction partners. Experimental procedures Plasmids and recombinant proteins A...
PF performed research, analyzed the data and wrote the manuscript; DC was responsible for the design of the study, interpretation of data and writing of the manuscript; XW, BL, YL, WL, JZ, and ZL performed research; YZ were responsible for the Data set analysis, JY, BZ, JL, and CJ ...