ResultsTotal concentrations of IGFBP-1 in media were higher and the highly phosphorylated isoforms were dominant in low oxygen conditions. Phosphorylation of IGF-I receptor by IGF-I was attenuated in low oxygen conditions. IGF-I-induced phosphorylation of insulin receptor substrate-1 (IRS-1) was ...
(hyperplasia). As a result, pharmaceutical research has discovered various methods of modifying the IGF-1 structure in order to circumvent or avoid this problem of IGF-1 molecules becoming bound by binding proteins. The results are, of course, the different variants of IGF-1 that have been ...
IGF-1 (IGF-I, insulin-like growth factor-1 or somatomedin C) is a secreted factor that circulates in complex with IGFBP-3 or IGFBP-5 with ALS. It signals through dimeric IG... Show More 212 results for "IGF-I/IGF-1" in Products Sort by: ...
GH both increased (P<0.05) mammary SOCS1 expression and decreased (P<0.05) mammary expression of tryptophan hydroxylase 1, the rate-limiting enzyme in the synthesis of serotonin and a potential feedback inhibitor of lactation. These results suggest that while both GH and IGF-I stimulate milk ...
4.1.1. Proliferation and Migration Stem Cells Results from Durgam et al. [76] and Raghavan et al. [77] confirm the positive effect of IGF-1 on cell proliferation. Equine MSCs, cultured with 100 ng/mL IGF-1 on a tendon matrix for 7 days, showed higher cell proliferation than cells with...