生长激素缺乏症(growth hormone deficiency, GHD)是较常见的可治愈的矮小症病因之一。但是GHD的诊断一直缺失一个真正的“金标准”。生长激素(growth hormone, GH)激发试验是常规检测GHD的方法,但是GH激发试验的敏感性和特异性有局限,且存在15%假阴、假阳的可能性,可能造成误诊或漏诊[1]。 此外,生长激素激发试验还...
Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents...
生长激素激发试验主要是与生长激素缺乏症(growthhormone deficiency,GHD)进行鉴别。 2.GH/IGF-1轴功能评价 测定血清IGF-1和IGFBP-3水平。血清IGF-1和IGFBP-3的测定受到很多因素的影响,例如营养状况、并发疾病和青春期等,因而所应用试剂...
However, the specific mechanisms through which aging, GH/IGF-1 deficiency, and obesity interact to promote the development of cardiovascular disease remain unclear. To test the hypothesis that low circulating GH/IGF-1 levels exacerbate the pro-oxidant and proinflammatory vascular effects of obesity, ...
Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. J Gerontol A Biol Sci Med Sci. 2012;67:553-564. doi:10.1093/gerona/glr197Bailey-Downs LC, Sosnowska D, Toth P, et al. Growth hormone...
An IGF-1 test is used to diagnose growth hormone disorders, including: • GH deficiency. In children, GH is essential for normal growth and development. A GH deficiency can cause a child to grow mor...
one (GH) Deficiency Insulin-Like Growth Factor-1 (IGF-1) Screening for the Diagnosis of Growth Hormone (GH) DeficiencyInsulin-Like Growth Factor-1 (IGF-1) Screening for the Diagnosis of Growth Hormone (GH) DeficiencyHumansGrowth Hormone
生长激素（growth hormone, GH）/胰岛素样生长因子-1（insulin-like growth factor 1,IGF-1）轴通过IGF-1R/Akt/mTOR信号通路调控机体生长发育和代谢【14-16】。一直以来，抑制IGF-1R被认为是促长寿的经典策略【17】。另外，随年龄增加，机体中IGF-1水平逐渐降低【18】。生理性衰老中progerin的累积与IGF-1/Akt...
1.IGFBP3 and their ratio ofIGF一1/IGFBP一3 with dwarf ism due to def iciency of GH. 【Key words】 Growth hor mone def iciency;Insulin—like growth factor 1;Insulin growth factor binding protein 3;Relevance 生长激素缺乏型矮小症(growth hormone deficiency, GHD)与患者的内分泌有较大关系 J。
1.1.2 矮小组的患儿均为2003年— o05年在我院因矮小 表 1 各组IGF一1和IGFBP一3检测结果 住院治疗 的儿童 ,分为完全生长激素缺乏组 (comp]ete growthhormonedeficiency,CGHD)部分生长激素缺乏组 (partialgrowthhomronedeficiency,PGHD)和特发性矮小症 组 (IdiopathicShortStature,ISS)。完全生长激素缺乏组45 例...