lgD分为两型:血清型IgD的生物学功能尚不清楚;膜结合型IgD(mlgD)构成BCR,是B细胞分化发育成熟的标志,未成熟B细胞仅表达mlgM,成熟B细胞可同时表达mlgM和mIgD,称为初始B细胞(naive B cell)。活化的B细胞或记忆性B细胞表面的mlgD会逐渐消失。
IgM and IgD expression during Bcell development and differentiation is strictly and developmentally controlled. Although studies have suggested subtle differences in Bcell activation, tolerance, and affinity maturation when antigens ligate cell membrane IgM or IgD, the mechanisms that may explain these ...
(1993) Human IgM+ IgD+ B cells, the major B cell subset in the peripheral blood, express VK genes with no or little somatic mutation throughout life. Eur. J. Im- munol. 23: 3272-3277.Klein, U, Kuppers, R, Rajewsky, K.Human IgM+IgD+ B cells, the major B cell subset in the ...
正常人血清中IgD含量很低,仅占血清免疫球蛋白总量的0.2%。IgD可在个体发育的任何时间产生,半衰期2.8天。血清IgD的生物学功能尚不清楚,膜结合型IgD(mIgD)构成BCR,是B细胞分化发育成熟的标志,未成熟的B细胞仅表达mIgM,成熟B细胞可同时表达mIgM和mIgD,称为初始B细胞(naive B cell);活化的B细胞或记忆B细胞其表面的m...
A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgDexpression ...
IgD在人体内有两种形式，一种是分泌型的，存在于血清中，功能尚不明确，另一种是膜结合型，存在于B...
血清IgD的生物学功能尚不清楚,膜结合型IgD(mIgD)构成BCR,是B细胞分化发育成熟的标志,未成熟的B细胞仅表达mIgM,成熟B细胞可同时表达mIgM和mIgD,称为初始B细胞(naive B cell);活化的B细胞或记忆B细胞其表面的mIgD逐渐消失。IgE是正常人血清中含量最少的免疫球蛋白,主要由黏膜下淋巴组织中的浆细胞分泌。其重要特征...
该IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) (IGHD/2730R), 0.2mg/mL产品反应性待更新请参考产品说明书 保存建议 室温 其他 Biotium公司是一家在荧光技术领域独树一帜的生物技术公司,公司位于美国加利福尼亚的BAY AREA---中外知名首要的生物科技中心。该公司一直致力于开发和生产用于生物医学研究...
Local class-switch recombination has been intimated but B cell precursors and mechanisms remain elusive. Here we describe the dynamics underlying the generation of IgE-antibody secreting cells (ASC) in human nasal polyps (NP), mucosal tissues rich in ASC without germinal centers (GC). Using VH ...
1.血清免疫球蛋白总量的0.2%。铰链区较长,易被蛋白酶水解,故半衰期仅3天。 2.膜结合型IgD(mIgD)是BCR的重要组成成分,为B细胞分化发育成熟的标志。未成熟B细胞仅表达mIgM,成熟B细胞同时表达mIgM和mIgD,被称为初始B细胞(naive B cell),活化的B细胞或记忆B细胞的mIgD逐渐消失。