detects the IgA class of anti-tissue transglutaminase antibody (anti-tTG). If a person has a deficiency in IgA, then results of this test may be negative when the person, in fact, has celiac disease. If this is suspected to be the case, then a quantitative test for IgA may be ...
Results: Complete data (signal intensity, tTG concentration and IgA concentration) was available for 8964 accession numbers. RU values were significantly lower in IgA deficient samples (IgA <0.1 g/L; N=39; median RU=5, range: 1-45) compared to IgA-sufficient samples (N=8925; median RU=...
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目的研究lncRNA XIST在IgA肾病(IgA nephropathy,IgAN)Th17细胞中的表达及功能作用,探讨lncRNA XIST对TLR9 mRNA表达的调控作用。 方法(1)外周血单个核细胞(peripheral blood mononuclear cell,PBMC)体外分离出CD4+T细胞并诱导其分化为Th17细胞...
The test yielded four (4) false positive results. Two patients with positive IgG anti-tTG were negative on CD-LFIA, but were classified as CD negative based on biopsy results and patient follow-up. The remaining 33 patients were found negative by both methods. The specificity and sensitivity ...
Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti–tissue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include meas...
Main autoantigens in DH are enzymes of the transglutaminase family [8, 9]: epidermal transglutaminase (eTG) and closely related tissue transglutaminase (tTG). They are considered to be autoantigens ...Gornowicz J, Bowszyc-Dmochowska M, Dmochowski M. IgA antibodies against fusion protein ...
(Fwd: AGCTGACCCCCTAACGTTCTT; Rev: AAAGCCCTGCTGGAGTCATTTG) for exon 1, and (Fwd: TGAGCAGGGAACGTCATACAAT; Rev: ATCCAGAAAAGGGGACAGCAAAG) for exon 2. To confirm genotypes, PCR products were sent to GENEWIZ for sanger sequencing. Mice were retro-orbitally bled at three weeks of age, an...
Data are presented as mean ± SD or mean ± SEM, and statistical analyses were conducted using Prism 8 software. Analysis of variance and the 2-tailed unpaired Student's t test were performed to assess differences between means, and P < 0.05 was considered statistically significant.Results...
It is fragmented in the small intestine and the resulting peptides are deamidated by the enzyme tissue transglutaminase (tTG) which itself has been identified as the major CD autoantigen. Recently, it was shown that certain deamidated gliadin peptides are powerful immunogens and that antibodies ...