In addition, HDL-cholesterol levels were significantly lower in men with biopsy-confirmed celiac disease (0.42.±0.12 vs. 0.90±0.30; p<0.05). Our results show a high correlation between IgA anti-tissue transglutaminase testing and endoscopy with biopsy as the gold diagnostic standard....
and crypt hyperplasia in biopsies obtained upon esophagogastroduodenoscopy has been the cornerstone for the diagnosis of celiac disease. Presence of celiac disease-specific IgA-class autoantibodies, determined by endomysial (EmA) and transglutaminase 2 autoantibody (TG2-Ab) assays, supports the diagn...
Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease. Clin Gastroenterol Hepatol. 2006;4:1112–7 8. http://www.worldgastroenterology.org/UserFiles/file/guidelines/celiac-disease-english-2016.pdf 9. Barbato M, Maiella G, Di Camillo C, et al. The anti-...
one test for celiac disease detects the IgA class of anti-tissue transglutaminase antibody (anti-tTG). If a person has a deficiency in IgA, then results of this test may be negative when the person, in fact, has celiac disease. If this is suspected to be the case, then a quantitative ...
Introduction: Dermatitis herpetiformis (DH) is a chronic, intensely itchy, blistering skin manifestation of gluten sensitive enteropathy, commonly known as celiac disease. Epidermal transglutaminase and closely related tissue transglutaminase are considered to be autoantigens in DH. Direct immunofluorescence ...
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed a genome-wide associati
In addition, pertinent laboratory testing for the associated conditions, e.g., recurrent infections, allergies, or celiac disease, should be performed. Celiac disease screening should include IgG isotype antibodies against gliadin and tissue transglutaminase since IgA isotype antibodies may not be ...
Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti–tissue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include meas...
The serological diagnosis of celiac disease (CD) often relies on the presence of anti-tissue transglutaminase (tTG) IgA autoantibodies. Patients suffering from selective IgA deficiency (IgAD) are often not aware of their IgA deficiency and are tested as CD negative, delaying considerably the diagnosi...
We investigated whether taking into account IgA anti-tissue transglutaminase antibody concentration (IgA anti-tTG) and total IgA concentration could improve clinical interpretation of serologic testing for celiac disease (CD). We retrospectively identified 43 consecutive newly diagnosed CD patients and 545 ...