Objectives: IgA-based serological testing is used in diagnosis and monitoring of celiac disease (CD). IgA deficiency occurs more frequently in CD patients. Deficiency may be discernable from the signal intensity obtained in IgA-tTG assays. We determined a signal cut-off to identify IgA deficient ...
Selective IgA deficiency (IgAD) is the most common primary immunodeficiency, frequently leading to only minor clinical complaints. IgAD may be associated with autoimmune diseases such as celiac disease (CeD). Although IgAD is thought to precede CeD and autoimmunity, the association between the two co...
The serological diagnosis of celiac disease (CD) often relies on the presence of anti-tissue transglutaminase (tTG) IgA autoantibodies. Patients suffering from selective IgA deficiency (IgAD) are often not aware of their IgA deficiency and are tested as CD negative, delaying considerably the diagnosi...
I've never posted here before, but you all are my people 100%. So I have a question for you. I got diagnosed via blood test and endoscopy in Sept '23 for Celiac. I know some people get bummed out when they get their diagnosis, but I was over the moon! I wasn't crazy after ...
is about 10 to 15 times more prevalent in patients with celiac disease (CD) compared with the general population.11,12 The presence of selective IgA deficiency often leads to a delay in diagnosis of CD because of the lower detection rates of IgA autoantibodies through serologic testing. ...
Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti–tissue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include meas...
one test for celiac disease detects the IgA class of anti-tissue transglutaminase antibody (anti-tTG). If a person has a deficiency in IgA, then results of this test may be negative when the person, in fact, has celiac disease. If this is suspected to be the case, then a quantitative ...
(2003) Cataldo et al. American Journal of Gastroenterology. Selective IgA deficiency (IgAD) and celiac disease (CD) are frequently associated and share the ancestral haplotype human leukocyte antigen (HLA)-8.1, which is characterized by a peculiar cytoki
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed a genome-wide associati
Excessive numbers of follicular helper T cells as seen in several mouse models, like the 'san' mutation in the RNA binding protein Roquin38 and PD-1 deficiency39, drive survival of GC B cells with a low degree of mutation and affinity and cause increased autoreactivity possibly due to a ...