Number of spots per well represents number of splenocytes secreting IFN- γ in after exposure to irradiated STOSE-luc target cells Conclusions MEM-288 has potent anti-tumor activity in an immune competent ovarian cancer mouse model, likely through recruitment of cytotoxic T-cells and promotion ...
FIG. 1. HEK-293T cells were transfected with pISRE-Luc, pRL-CMV, and pEGFP-C1 expression plasmids encoding indicated proteins. 24 h after transfection, 1000 IU/ml of recombinant IFN-β were added. After 24 h of incubation, the relative luciferase activities of IFN-treated cells were determin...
RESULTS: In vitro studies with HSCs demonstrate that TGF-beta-dependent activation of (CAGA)9-MLP-Luc, a Smad3/4 responsive reporter construct, was significantly decreased by IFN-gamma, indicating a TGF-beta antagonizing function. IFN-gamma induced the activity of the Smad7 promoter and Smad7 ...
Jean-LucUngureanu-LongroisDanEBSCO_AspAmerican Journal of PhysiologyBalligand J, Ungureanu-Longrois D, Simmons WW et al. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol 1995;268:H1293-H303....