The lncRNA, Interferon gamma-antisense RNA (IFNG-AS1), regulates expression levels of the Interferon gamma (IFNG) gene. In the present study, we investigated expression of IFNG and IFNG-AS1 in 50 children with ASD (15 females and 35 males, mean age: 6 +/- 1.4 years) and 50 healthy ...
Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice Yu Fu, Yuan-lin Zhang, Rong-qi Liu, Meng-meng Xu, Jun-ling Xie, Xing-liao Zhang, Guang-ming Xie, Yao-ting Han, Xin-Min Zhang, Wan-ting...
The results showed significant up-regulation of IFNG and down-regulation of IFNG-AS1 expression in children with ASD compared to controls (Fold change=1.5, P<0.0001; Fold change=-0.143, P=0.013, respectively). The IFNG expression level increase was more pronounced in male ASD children (Fold ...
目的 探讨IFNG基因相关的长链非编码RNA IFNG-AS1单核苷酸多态性(lncRNA IFNG-AS1 SNP)与桥本甲状腺炎(HT)易感性之间的关系。方法 选取福建地区汉族HT患者70例和相应健康体检者109例为研究对象,应用TaqMan探针技术进行单核苷酸多态性位点(rs10878724、rs7980829和rs11177020)分型检测,采用实时荧光PCR法...
目的 探讨 IFNG 基因相关的长链非编码 RNA IFNG-AS1 单核苷酸多态性( lncRNA IFNG-AS1 SNP)与桥本甲状腺炎(HT)易感性之间的关系.方法 选取福建地区汉族HT患者70例和相应健康体检者109例为研究对象,应用TaqMan探针技术进行单核苷酸多态性位点( rs10878724,rs7980829和rs11177020)分型检... 查看全部>>关键词:IFNG...
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为了探讨长链非编码RNA干扰素活化基因的反义核糖核酸(lncRNA IFNG-AS1)对氧化型低密度脂蛋白(oxLDL)诱导的人脐静脉血管内皮细胞EVC-304增殖,凋亡的影响和调控机制,该研究采用100 μg/mL的oxLDL分别处理转染si-IFNG-AS1,miR-19b-1-5p mimics或共转染si-IFNG-AS1与anti-miR-19b-1-5p的EVC-304细胞,利用实时...
LncRNA Ifng antisense RNA 1 (IFNG-AS1), a key regulatory factor in the immune system, also named NeST or TMEVPG1, is proximally located to IFNG and participates in the regulation of it. The dysregulation of IFNG-AS1 is implicated in the pathogenesis of several autoimmune diseases. This ...
IFNG/IFNG-AS1 expression level balance: implications for autism spectrum disorderAutism spectrum disorder (ASD)INFGINFG-AS1Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with different epidemiological, genetic, epigenetic, and environmental factors. Although its etiology is not ...
The chi-square test was used to analyze the association between tissue IFNG-AS1 and clinical characteristics. Functional experiments were conducted to delve into the effects of IFNG-AS1 on cellular activities (cell viability/migration/invasion). The target miRNA of IFNG-AS1 was also explored. IFNG...