Melanoma, PD-L1, CD274, p53, TP53, JAK2BackgroundImmune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associated with better clinical response and...
当在上述模型中应用IFNγKO CAR-T或使用IFNγ阻断抗体时,细胞因子产生减少,巨噬细胞活化减弱,活化标志物CD86/CD69表面表达降低,下游IFN-γ受体信号降低以及更低的PD-L1表达。 研究人员也开发了体内体外杂交模型以评估巨噬细胞活化。在体外,经CAR-T或IFNγKO CAR-T治疗的Nalm6荷瘤小鼠血清被添加到供体匹配的巨噬...
Release of Exosomal PD-L1 in Bone and Soft Tissue Sarcomas and Its Relationship to Radiotherapy Authors - Keisuke Yoshida View Article human serum Oncoimmunology Novel BCMA-OR-CD38 tandem-dual chimeric antigen receptor T cells robustly control multiple myeloma. Authors - Yaru Feng View Article human...
Overexpression of PD-L1 Correlates with JAK2-V617F Mutational Burden and Is Associated with Chromosome 9p Uniparental Disomy in MPN Myeloproliferative neoplasms (MPN) are characterized by clonal hematopoiesis, hyperproliferation of myeloid cells, hyperinflammation and immune deregulatio... JDM Feenstra,F ...
CPI-203 improves the efficacy of anti-PD-1 therapy by inhibiting the induced PD-L1 overexpression in liver cancer. Authors - Xiaoge Niu View Article See more citations Reviews The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feed...
¥2200/100 μL Cat No.10808-1-AP 浓度:1000 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 human,mouseWB KD Validated View Article mouseWB,IHC Ecotoxicol Environ Saf Silica-induced macrophage pyroptosis propels pulmonary fibrosis through coordinated activation of relaxin and osteoclast differenti...
Biliary epithelial cells (cholangiocytes) respond to proinflammatory cytokines such as IFN-gamma and actively participate in the regulation of biliary inflammatory response in the liver. B7-H1 (also known as CD274 or PD-L1) is a member of the B7 costimulatory molecules and plays a critical immu...
In the PROSPECT cohort (14 m vs 80 WT), we compared 10 immune markers by IHC (PD-L1, PD-1, CD3, CD4, CD8, CD45RO, CD57, CD68, FoxP3 and Granzyme B) and 44 immune regulator genes' expression levels and pathway signatures from microarray data. We subsequently validated the ...
Human Endothelin-1 ELISA Millipore-BBE5L1 Human Cancer Biomarker 6-Plex Millipore-BCBP06L1X Beadlyte Human Isotyping Panel 3-Plex Millipore-BHISO03L1X Canine Gut Hormone Panel 1-plex Millipore-CGT01L1X Canine Gut Hormone Panel 2-plex Millipore-CGT02L1X Canine Gut Hormone Panel 3-plex...
Moreover, studies have shown that the activation of EGFR induces the secretion of programmed death ligand 1 (PD-L1) to inhibit the function of T cells [13]. In summary, studies reveal that EGFR signaling can reshape the TME [14], while the role of TMEs and cytokines in the activation ...