The present disclosure describes IFN-纬 gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for...
and intra-tumoral stem-like T cells from CD8-IFNγRKO mice displayed enhanced Wnt/β-catenin transcriptional signature score compared to control cells (Fig.S6c), we investigated whether IFNγ interfered with the Wnt/β-catenin pathway. Surprisingly, we found that β-catenin expression was increase...
IFNγ signature A pattern of elevated expression of canonical IFNγ target genes in inflamed tissues; it is often detected in samples from patients with autoimmune disease. Endotoxin tolerance Classically, a macrophage cell state in which prior exposure to lipopolysaccharide (LPS; an endotoxin) renders...
PBL Assay Science提供各种干扰素亚型的蛋白,抗体和检测试剂盒,如:IFN-Alpha(IFN-ɑ 2a,IFN-ɑ 2b,IFN-ɑ 5,IFN-ɑ 6,IFN-ɑ 7,IFN-ɑ 14,IFN-ɑ 16,IFN-ɑ 17...),IFN-Beta(IFN-β 1a,IFN-β 1b),IFN-Lambda(IFN-λ),IFN-Omega(IFN-ω),IFN-Gamma(IFN-γ)... 武汉艾美捷科技有限公司,...
IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus. Lee YM;Miyahara N;Takeda K;.IFN-gamma production during initial infection determines the outcome of reinfection with respiratory syncytial virus.Am J Respir......
IL-12是Th1细胞发育和IFNγ分泌所必需的,所述IFNγ是通过刺激MHC表达、B细胞类别转换成IgG亚类及活化巨噬细胞在免疫性中起重要作用的细胞因子(Gracie,J.A.et al.,"Interleukin-12 induces interferon-gamma-dependent switching of IgG alloantibody subclass",Eur.J.Immunol.,26:1217-1221(1996);Schroder,K.et...
IFN-纬 deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune responsePrevious studies have shown that interferon-gammaZhangHongLiangAzimullahSheikhZheng Zhang,HongLiang,Azimullah,... - 《Journal of Neuroimmunology Official Bulletin of the Research Committee on...
The results from gene signature and gene ontology enrichment were used to create heatmap visualisations. For each meta-profile the top 100 most enriched signatures and 100 most enriched GO terms were used to construct a matrix of signatures against genes. This is a binary matrix with 1 s depi...
“help” signature denoting enrichment of the indicated pathways (FDR < 0.05) using the Reactome database.BHeatmap depicting scaled expression values of the genes involved in the “helped” cDC1-enriched IFN-I response pathway.C–JPurified cDC1s were stimulated with anti-CD3/CD28-activated ...
其中,替代性活化的巨噬细胞(aaMphi)参与了细胞生长、血管生成、免疫抑制、组织修复和间质形成等过程。肺... 章必成 - 《第三军医大学》 被引量: 4发表: 2008年 A Novel Lymphangiogenesis-Related Gene Signature can Predict Prognosis and Immunosuppressive Microenvironment in Patients with Clear Cell Renal Cell...