Hirsch, NK cells secrete high levels of IFN-gamma in response to in vivo administration of IL-2, Eur J Immunol 31 (2001) 3355-3360.Thornton S,Kuhn KA,Finkelman FD,et al.NK cells secrete high levels of IFN-gamma in response to in vivo administration of IL-2.European Journal of ...
and host response to pathogens response γ lrrk2 is involved in the ifn The early release of cytokines by cells involved in innate immunity is an important host response to intracellular pathogens. Gamma interferon (IFN-gamma) ... P Rioux,MJ Daly,RJ Xavier,... 被引量: 0发表: 2019年 Ide...
However, keyhole limpet hemocyanin (KLH)-priming of IFN-gko mice readily elicited both T cell and antibody responses, suggesting that IFN-gamma regulates the humoral immune response distinctly to self (AChR) versus foreign (KLH) antigens. We conclude that IFN-gamma is required for the generation...
(CD4+) cells. IFN-gamma signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally,IFN-gamma stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of ...
Interferon-gamma regulates the T cell response to precursor nevi and biologically early melanoma. To examine the potential regulatory role of interferon-gamma in the cellular immune response to melanoma and its precursor lesions, we have tested the capacity of this lymphokine to enhance HLA class ...
Autophagy facilitates an IFN-γ response and signal transduction. Microbes Infect. 2011, 13(11):888-894. [4] Giammarioli AM, Vona R, Gambardella L, Ascione B, Maselli A, Barbati C, Tinari A, Malorni W. Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. FEBS...
In this study, we addressed whether and how YopH might affect the innate immune response in mice. Upon infection with Y. enterocolitica O8 strain WA-314 (pYV+) or a YopH deletion mutant (ΔyopH) alterations in gene expression in CD11b+ cells was analyzed. These cells include mostly gran...
cruzi infections. The results reveal differences between both mouse strains in the mechanisms controlling the onset and fate of the Th1 response triggered by the parasite and a long lasting pro-inflammatory stimuli. 展开 关键词: T-cruzi IFN-gamma IL-12 NK cell activity Th1 ...
Among these cells, pDC produces massive amount of IFN-alpha in response to CpG-ODNs37. As such, we next tested IFN-alpha production from blood cells in the same experimental setting. We observed remarkable production of IFN-alpha when blood samples were stimulated with a combination of eMDP1...
IFN-gamma is an effector cytokine of cell-mediated immunity that plays an essential role in both innate and adaptive phases of an immune response. Interestingly, in several Th1-dependent autoimmune models, lack of IFN-gamma is associated with an acceleration of disease. To distinguish the influence...