我们筛选了一个小化合物A366,它可以显著提高ROSI胚胎的发育潜力,其中A366可以通过修改表观遗传和转录组状态来部分克服重编程缺陷。总之,我们的研究揭示了ROSI胚胎的重编程缺陷,为理解潜在的发育潜能受损机制提供了一条优化ROSI技术的途径。 6 英文题目:Primary specification of blastocyst trophectoderm by scRNA-seq: N...
(A) Glial cells were treated with tunicamycin (Tm: 1 mg/mL) for 1 h and then stimulated with PGE2 (15 mM) 1 IFNc(20 ng/mL) for 24 h iNOS protein levels were detected by Western blotting. PGE2 1 IFNc-induced iNOS expression was inhibited under ER stress. ***p , 0.001 PGE2 1 ...
Under a Creative Commons license open accessHighlights • Conventional nerve conduction studies, H-reflex studies, and needle electromyography are important tools for the diagnosis of Motor Neuron Disease (MND) • High-density surface EMG, nerve excitability testing, electrical impedance myography, MUN...
Alzheimer’s disease (AD) is a progressive, clinically heterogeneous, age-sensitive neurodegenerative disease, characterised by often escalating impairments of memory and other cognitive functions together with associated changes in personality and behaviour [1,2,3]. Amyloid plaques and neurofibrillary tangl...