In this study, we investigated the effects of CP-AMPAR blockade on the development of epileptiform activity in mouse entorhinal cortex slices using the selective blocker IEM-1460. Epileptiform activity was induced by 4-aminopyridine-containing perfusing solution with increased potassium ion concentration ...
在子类型之间选择;与含有GluA2的受体相比,阻断GluA2缺乏亚基的受体更有效(KD表示含GluA2的AMPAR在-80 mV时高210倍)。由于解堵速率较慢,因此比IEM 1460和IEM 1754更有效。减轻大鼠周围炎症模型的炎症性疼痛。 储存温度 -20°C储存,充氩,干燥 运输条件 超低温冰袋运输 产品介绍 AMPA receptor antagonist ...
To obtain an insight into the therapeutic approach to such a glutamate-linked psychotic state, we have studied the effects of the systemic administration of the CP-AMPAR-selective antagonist, IEM 1460 (N,N,N-trimethyl-5- [(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide ...
Induction of CP-AMPAR-dependent plasticity is blocked by the CP-AMPAR inhibitor IEM-1460.Suhail AsrarZikai ZhouWei RenZhengping Jia