把表位长度确定好之后,重新将G12D、G12V、G12R、G13D重新进行IEDB的MHC-I Binding Prediction。 结果显示,四条突变序列相对于野生型序列都可以找到大量的突变位点特异性的且具备一定较高亲和力的HLA-I型别,即在标红的HLA-I型别患者中,有可能设计出肿瘤特异性抗原。
Example of online output from IEDB peptide-MHC class I binding predictor.Stephen, J. GoodswenPaul, J. KennedyJohn, T. Ellis
IEDF IEDG IEDI IEDK IEDLF IEDM IEDMS IEDMT IEDN IEDP IEDR IEDRC IEDRO ▼ Complete English Grammar Rules is now available in paperback and eBook formats. Make it yours today! Advertisement. Bad banner? Pleaselet us knowRemove Ads
The initial release focuses on consolidation of all tools related to HLA class I epitopes (MHC binding, elution, immunogenicity, and processing), making all of these predictions accessible from a single application and allowing for their simultaneous execution with minimal user inputs...