Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventionsIDIOPATHIC pulmonary fibrosisUNFOLDED protein responseTRANSFORMING growth factorsPLATELET-derived growth factorCOVID-19PROTEIN foldingENDOPLASMIC reticulum...
The depletion of B cells results is dramatic improvement in IgG4-RD and there are some data that argue that B cell depletion may benefit patients with SSc as well. Since there is no firm evidence to suggest that autoantibodies contribute to fibrosis in either of these diseases, we posit that...
In this Seminar, we summarise the presentation, pathophysiology, diagnosis, and treatment options available for patients with idiopathic pulmonary fibrosis. This disease has improved understanding of the mechanisms of lung fibrosis, and offers hope that similar approaches will transform the management of ...
Insights into the pathophysiology have revealed novel areas for therapeutic intervention. These advances have helped clarify many important diagnostic and therapeutic issues in this disease. An effective treatment regimen is yet to be determined. Significant new insights in the natural course and ...
Noncoding RNAs (ncRNAs) play regulatory roles in various biological processes and have been implicated in the pathophysiology of multiple fibrotic diseases, including IPF. This review summarizes the roles of ncRNAs in the pathogenesis of IPF and their potential as diagnostic and therapeutic targets....
This review focuses on the roles of NADPH oxidase/NOX proteins in idiopathic pulmonary fibrosis (IPF) pathophysiology and in the signalling pathways involved in IPF. NOX proteins are membrane-associated multi-unit enzymes that catalyze the reduction of oxygen using NADPH as an electron donor. Recent...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive respiratory disease. It is distinguished by the formation of fibrous tissue in the lungs, which leads to irreversible lung dysfunction [1]. IPF has varying occurrence and prevalence rates, ranging from 0.09 to 1.30 and 0.33 to 4.51...
Idiopathic pulmonary fibrosis (IPF) is a chronic lethal lung disease, the prevalence and incidence of which dramatically increase with age. Novel therapeutic interventions for IPF are necessary as approved therapies are limited to slowing the progression of the disease. Similar to other age-related di...
Despite the tremendous advancements in the knowledge of the pathophysiology and clinical aspects of SARS-CoV-2 infection, still many issues remain unanswered, especially in the long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one of the most severe complications associated...
Conversely, Xrs was believed to be more important for the assessment of ILD pathophysiology, as the current study demonstrated. Fujii et al. (2015) found that Fres in the inspiratory phase correlated with the FVC, FEV1, DLCO, and fibrosis score in ILD. Sugiyama et al. (2013) reported that...