近日，法国巴黎萨克雷大学Birgit Geoerger团队在Nature Medicine期刊上发表题为Enasidenib treatment in two individuals with D-2-hydroxyglutaric aciduria carrying a germline IDH2 mutation 的Brief Communication，报告了2例D2HGA2患儿（其中1例表现为严重的扩张型心肌病）使用选择性突变型IDH2抑制剂Enasidenib治疗的...
We investigated 60 unique samples [43 bone marrow (BM) and 17 peripheral blood (PB), Figure 1(A)] at different time points of AML treatment of eight patients with AML harboring the IDH2 mutation c.G419A (p.R140Q) who were previously or currently being treated in our institution from ...
In our study, theIDH2-R140 mutation was associated with superior outcomes in the entire NK-AML, uniquely when accompanied byNPM1mutations, confirming the previous results8. Interestingly, this effect was not onlyNPM1mutation-dependent, but alsoIDH2-specific: we found the favorable effect ofNPM1...
Keywords IDH2inhibitor;acutemyeloidleukemia 复发/难 治性急性髓系白血病 (acute myeloid leukemia,AML)患者的预后较差 ,长期存活率低于 25% . 随着分子诊断水平的提高 ,个体化靶向治疗 近年来发展迅 速,多种小分子靶向药物进入临床, 为一些复发/难治性 AML 患者带来再次获得缓解 的机会.伴有IDH2 突变的 AML ...
[1] FDA Grants Approval of IDHIFA®, the First Oral Targeted Therapy for Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and an IDH2 Mutation [2] Celgene, Agios win a landmark FDA OK for new AML drug Idhifa [3] FDA approves new targeted treatment for relapsed or refractory...
The IDH1 mutation was determined to be sub-clonal in 28% of patients (and clonal in 72%), and with no association of clonal hierarchy to ivosidenib response was identified28. Newly diagnosed IDH1-mutated AML There were 33 patients with newly diagnosed/treatment-naïve IDH1-mutated AML that ...
Acute myeloid leukemia with IDH1 or IDH2 mutation: frequency and clinicopathologic features. Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are reported in acute myeloid leukemia (AML). We studied the frequency and the clinicopat... KP Patel,F Ravandi,D Ma,... - 《Americ...
higher RR. Conciusion 1.IDH mutation is one of the mutational genes in AML. 2.IDH mutation in AML are possibly associated with poor prognosis. 3.IDH mutation may provide basis for the layered treatment of the leukemia. Key words:leukemia,myeloid,acute;IDH 1 mutation;IDH2 mutation;prognosis ...
In CN-AML, multivariable analyses revealed a significant interaction between IDH mutation and the genotype of mutated NPM1 without FLT3-ITD (ie, the adverse impact of IDH mutation [RFS]; P = .046 was restricted to this patient subset). CONCLUSION: IDH1 and IDH2 mutations are recurring ...
Therefore, it is necessary to identify IDH2/R140Q inhibition-independent strategies for the treatment of IDH2/R140Q-mutated AML. Malignant proliferation is an important hallmark of IDH-mutated AML. IDH2/R140Q or mutation of arginine to histidine at position 132 (R132H) of IDH1 promotes ...