The free energy calculation provides a quantitative estimation of interactions between protein and ligand that help to understand the stability of that protein–ligand complex. The binding free energy including the free solvation energy (polar and nonpolar solvation energies) and potential energy (electros...
In contrast to the evenly distributed silent mutations, pathogenic single amino acid mutations are concentrated at transmembrane segments S1 to S6, the pore loop, and intracellular helices A and B of Kv7.2 (Fig.1b). To test if this trend was statistically significant, we developed a resampling ...
contrast, the 8275A method utilises a thinner stationary phase allowing higher boiling point compounds to be eluted in a reasonable time. Other considerations are the polarities of the target analytes as hydroxyl containing hydrocarbons may be more easily separated from the nonpolar gases of bitumen...