We constructed the protein-protein interaction (PPI) network and the drug-target interaction network of DEGs and identified hub modules and genes using Cytoscape and analyzed immune cell infiltration in pediatri
Cytoscape and String were used to analyse modules and screen hub genes. The expression of the identified hub genes was confirmed in mdx mice through using qRT-PCR. Results In total, 519 DEGs were identified, consisting of 393 upregulated genes and 126 downregulated genes. The enriched ...
To identify the hub genes that associated with chemo-radiotherapy sensitivity for cervical cancer and to explore the relationship between hub genes and var
Bioinformatics analysis of geo datasets for identifying pathways and hub genes in psoriasis 来自 ACM 喜欢 0 阅读量: 19 作者:TarannumMasufa,PriyaRatna,PandeyShweta,JB Prakash 摘要: Psoriasis is one of the inflammatory skin diseases where skin cells divide at a faster rate. The present study aims...
Hub genes 1. Introduction Prostate cancer (PCa) is the major cause of cancer-related deaths among men worldwide, and it's been steadily rising in both developed and developing countries over the past thirty years [1]. In the United States, men with this type of cancer are the second most...
Nasopharyngeal cancer or nasopharyngeal carcinoma (NPC) is the most common cancer originating in the nasopharynx. The factors that induce nasopharyngeal cancer are still not clear. Additional information about the chemicals or genes related to nasopharyn
A total of 1269 up-regulated and 330 down-regulated genes were identified. The protein-protein interactions (PPI) network of DEGs was constructed by STRING V11 database, and 11 hub genes were selected through intersection of 11 topological analysis methods of CytoHubba in Cytoscape plug-in. All...
In a star sub-network, the central gene (the hub gene) has influence on its neighbor genes and possibly on the whole network. To identify a star module, FunMod calculates the sub-network centralization (CE) using the formula:(3)CE=n(n-2)×max(k)n-1-GDwhere max(k) is the highest...
Next, the K nearest neighbor genes of the central gene in the local net- work are selected based on the top K genes in terms of distance. Subsequently, based on reference samples, case samples are separately introduced at each time point, and the R en et al. BMC Bioinformatics (...
PPI network construction and hub genes recognition The Protein-Protein Interaction (PPI) network of DEGs was established through the online tool STRING (https://string-db.org/), which predicted interactions between proteins and determined the mechanisms of IgAN [22,23]. Interaction with a combined...