Building enhancer–gene maps is essential but challenging with current experimental methods in primary human tissues. Here we developed a nonparametric statistical method, SCENT (single-cell enhancer target gene mapping), that models association between enhancer chromatin accessibility and gene expression in...
longitudinal exome-wide association study (EWAS), which is suited to studying the effects of low frequency or rare variants within a gene of interest, to explore novel genetic variants that confer susceptibility to hypertension, focusing on rare coding variants, such as East Asian-specific alleles...
The allelic specificity of the HLA peptide binding groove in the pathogenesis of T cell mediated drug hypersensitivity is exemplified by the well characterized abacavir hypersensitivity syndrome which occurs bothin vivoandin vitroonly in association withHLA-B*57:01, and not with related B17 serotype ...
and liver. Syncytial cells develop in the liver cells of infected fish, which are characterized by widespread hepatocellular necrosis and karyolytic nuclei. It is a highly infectious virus that spreads both horizontally and vertically. Despite these devastating complications, there is still no cure or...
is impractical and time-consuming. Alternatively, automated approaches such as text mining can process the entirety of PubMed and retrieve the needed information within a few minutes to hours. Unlike EHRs, which have numerous limitations on access, PubMed is freely accessible without any restrictions...
The “B” genome is associated with the banana streak virus (BSV) [7], which influences the exchange of accessions between germplasm banks, field management, and in vitro cultivation. The virus has two forms of endogenous sequences (eBSV) in the “B” genome [8,9]: (i) incomplete ...
In addition, from another “One Health” perspective, conservation strategies of animal genetic resources should also evaluate the risk derived by the fixation or high frequency in a population of alleles associated with susceptibility (that are a matter of concern) or resistance (that are evaluated...