Each experiment was repeated three times. Full size image We further investigated the effects of IGFBP7 overexpression on tumor in a xenograft model. To do so, IGFBP7-expressing or control cells were subcutaneously injected into BALB/c nude mice. We found that IGFBP7 overexpression markedly ...
Identify the three populations of cells that help carry out the functions of the juxtaglomerular complex (JGC). Identify the structure from the given description: Cell that secretes mucin. Identify the given organelle/cell structure from the given definition: Produce(s) the bulk of th...
In addition, we confirmed three previously reported loci (FOXE1, NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SEPT11 and SLC24A6) associated with DTC. Furthermore, we identified specific variants of DTC that have different effects ...
Via the colocalization and Mendelian randomization analyses, we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues, which included genes, such as NADSYN1, NDUFS3, LTF and KIFC2 in liver, GRAMD1C, TMTC2 and ZNF613 in backfat, as ...
17,769 statistically fine-mapped GWAS variants (PIP > 0.2) across 82 UK Biobank traits16(average,n = 334,803; Supplementary Table3) in PBMC, pancreas and pituitary gland (Methods). SCARlink gene-linked tiles in the three multi-ome datasets show 5.5× to 7.5× enrichment of fine...
Specifically, MDFF utilizes information from three distinct dimensions of drug pairs as inputs, applying different feature encoders to extract 1D sequence features, 2D topological global and local features, and 3D geometric features of drugs. Afterward, it fully integrates these multi-dimensional ...
Briefly, tissue lysates from three samples each of the ML group and MN groups were prepared. Tissues were lysed in lysis buffer, transferred to new microtubes, mixed by pipetting, and incubated on ice for 10 min. The resulting lysates were triturated 10 times using a 26-G needle, then ...
Frohlich-Reiterer EE, Ong KK, Regan F, Salzano G, Acerini CL, Dunger DB: A randomized cross-over trial to identify the optimal use of insulin glargine in prepubertal children using a three-times daily insulin regimen. Diabet Med 2007;24:1406-1411....
Each screening cycle could be finished in three days post a single treatment of individual compound. Using Ken as a positive control, a Z-prime value ≥ 0.5 could be obtained for each assay. Fig. 1: Screens for chemicals improving survival of ALS-hiMNs. A A flowchart of the ...
et al. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J. Biol. Chem. 276, 30686–30693 (2001). CAS PubMed ...