Via the colocalization and Mendelian randomization analyses, we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues, which included genes, such as NADSYN1, NDUFS3, LTF and KIFC2 in liver, GRAMD1C, TMTC2 and ZNF613 in backfat, as ...
In addition, we confirmed three previously reported loci (FOXE1, NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SEPT11 and SLC24A6) associated with DTC. Furthermore, we identified specific variants of DTC that have different effects ...
Clinically, we establish a panel of 17 plasma metabolites that accurately diagnoses CRC in a discovery and three validation cohorts (AUC = 0.848–0.987). Overall, we characterize metabolite signatures, mechanistic significance, and diagnostic potential of plasma and fecal metabolomes in CRC. Graphical ...
Over a 2-year time period, we collected feces from 28 CC mouse strains, including three males and three females of each strain, and performed 16s rRNA gene sequencing. Individuals within a strain had similar microbiota composition, while there were significant differences between the strains startin...
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular
For part three, the druggability and possible side effects estimated by a phenome-wide MR were assessed for prioritizing these therapeutic targets. The P-values were all adjusted by the Benjamini–Hochberg false discovery rate (FDR) in multiple tests in our study. Fig. 1 Flowchart of the study...
Frohlich-Reiterer EE, Ong KK, Regan F, Salzano G, Acerini CL, Dunger DB: A randomized cross-over trial to identify the optimal use of insulin glargine in prepubertal children using a three-times daily insulin regimen. Diabet Med 2007;24:1406-1411....
many pharmaceutical products also fit this description. For example, synthetic insulin that is free of impurities couldn't disrupt the market for insulin made from a pig's pancreas (which contains some impurities) because neither is effective enough to counteract the long-term effects of Type 2 ...
The 12,714 annotated contigs were classified into three GO categories: biological processes, cellular compo- nents and molecular functions. The most prominent GO Cellular Component categories (Level 3) were organelles (51%) (Fig. 3a). The most prominent Molecular Function (Level 3) were ...
Type 2 diabetes (T2D) is a metabolic disorder characterized by high blood glucose levels and defective carbohydrate utilization due to a relative or absolute deficiency of insulin or insulin resistance with impairment of β- cell function5. However, obesity-induced perturbations in metabolism have...