To identify novel genetic risk variants underlying inhibitor development, we applied whole-exome sequencing (WES) analysis in a group of Italian patients with severe HA, followed by replication of our results in a larger cohort of severe HA patients with and without inhibitors. This manuscript repo...
NMR structural study, indicated that the binding of RFQV-peptide to OSR1-CTD induces large conformational changes that effect almost every amino acids within the CTD of OSR1 suggesting the crucial role of this domain in the regulation of whole signaling transduction (AlAmri et al., 2019). ...
These authors jointly supervised this work: Robert Kraaij, Jeroen Raes, Alexandra Zhernakova. Authors and Affiliations Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Alexander Kurilshikov, Ayse Demirkan, Daria V. Zhernakova, Marc Jan Bo...
In this section we compare the results between GraphPAC, iPAC and NMC in terms of the number of structures found (Section ‘Method comparison’) and describe the new proteins identified by GraphPAC (Section ‘GraphPAC identifies novel proteins with significant clustering’). We also show the res...
functional genomics and histopathology. This study was funded by the European Union under the Seventh Framework Programme (FP7-HEALTH-2013-INNOVATION-2, SUPPRESSTEM, grant agreement no. 601876). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from the Spanish Ministry of Econo...
This duplication has a complex structure and arose de novo on the maternal chromosome, likely as a result of a DNA replication error initiated by the adjacent large tandem repeat. Using bioinformatic and array CGH analyses of the minisatellite, we found a large variation of its size in several...
structure. the discriminating power of this consensus strategy was further enhanced by a chemical similarity-weighted scoring scheme, yielding better or comparable enrichment for all studied nrs. applying this optimized method, we screened 252 fatty acids against peroxisome proliferator-activated receptor ...
B-cell lymphoma (BCL) accounts for a considerable number of cancer cases1, with more than 300,000 new patients per year worldwide2. Diffuse large B-cell lymphoma (DLBCL) is the most common form of BCL. Patients with this aggressive disease are often diagnosed at advanced stages3. Next-gen...
In this systematic review, we addressed the following questions: 1) Which helminth species infect urban rats and what are their prevalence? 2) What are the methods used to investigate the helminths of urban rats? 3) What are the risk factors for infection in the rat host?
Attempts have been made to identify the mechanism of cisplatin resistance but this mechanism remains to be elucidated. In various studies, cisplatin resistance has been associated with reduced intracellular accumulation of the drug, increased DNA repair function and/or increased drug detoxification by int...