These authors jointly supervised this work: Robert Kraaij, Jeroen Raes, Alexandra Zhernakova. Authors and Affiliations Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands Alexander Kurilshikov, Ayse Demirkan, Daria V. Zhernakova, Marc Jan Bo...
Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate ...
The combinatorial genetic system of Cre-LoxP has been used to circumvent challenges associated with intrauterine development and map cell types resulting from neural crest lineages in the mouse. In this approach, expression of Cre protein from a “driver” transgene or knock-in allele results in re...
The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test th...
In this chapter we will discuss the various approaches including functional proteomics that have been used to uncover and characterise novel MYO6-associated proteins and complexes and how this work contributes to a fuller understanding of the targeting and function(s) of this unique myosin motor....
In this systematic review, we addressed the following questions: 1) Which helminth species infect urban rats and what are their prevalence? 2) What are the methods used to investigate the helminths of urban rats? 3) What are the risk factors for infection in the rat host?
We created a METSIM imputation reference panel of > 26M genetic variants by integrating genome and exome sequence and array genotypes in 2922 METSIM participants (“Methods”; Supplementary Table 3). We used this reference panel to impute genotypes in all METSIM participants. To discover ...
functional genomics and histopathology. This study was funded by the European Union under the Seventh Framework Programme (FP7-HEALTH-2013-INNOVATION-2, SUPPRESSTEM, grant agreement no. 601876). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from the Spanish Ministry of Econo...
Given the large unmet need in this population and the paucity of genetic data specifically for this disease, we developed this prospective study to perform molecular sequencing for patients with advanced neuroendocrine malignancies. The primary objective of this exploratory pilot project was to better el...
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