However, not all obese people are at an elevated risk of T2D. Obesity is closely linked to chronic inflammation. In addition, inflammation is an important contributor to T2D via the processes of insulin resistance and islet I3-cell failure. Therefore, we hypothesize that white blood cells (WBC...
Blood is composed of plasma and formed elements. The formed elements of blood can be divided into three forms: white blood cells (leucocytes), red...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
thewhite blood cellsthat help the body fight infection and repair tissue, are changed into two types as a response to changes in the microenvironment of the cell
When a virus, bacteria or foreign substance invades the body, specializedcellsknown as dendritic cells present in the skin and other organs capture the trespassers and convert them into smaller pieces called antigens that they then display on their cell surfaces. Whiteblood cellsknown as T and B...
ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role ...
Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RN
We interrogated the expression of the potentially causal gene (TMEM187) in peripheral blood mononuclear cells (PBMCs) from celiac patients at onset, on a gluten-free diet, potential celiac patients and non-celiac controls. Results The XWAS and gene-based analyses identified 13 SNPs and 25 ...
To ensure proper transduction rate during the screening, an in-line assay was performed in parallel. At the last day of the screen, genomic DNA was extracted from the remaining cells using the QIAamp DNA Blood Maxi Kit (QIAGEN) from which the integrated sgRNA sequences were PCR-amplified ...
classify white blood cell types33, and identify various types of HEp-2 cells34. However, all of these methods classify images containing a single, suspended cell. Classification of images containing multiple adherent cells are less common35but has been applied to identify subcellular features in pub...
genes. Previously healthy stem cells begin to express a new protein—PML/RARα—which blocks their differentiation. Eventually, the bone marrow fills up with abnormalwhite blood cellsknown as promyelocytes that lead to a shortage of other types of blood cells and prevent normal blood production....