These macromolecules cannot be absorbed through the muscosal cells of the small intestine, as they are too large. Therefore, they must be chemically digested by enzymes into their monomers, or building blocks. These monomers are then able to be absorbed into the blood stream....
SAIGE is efficient in testing the genetic association of large samples with case-control ratio imbalance and sample relatedness using the saddlepoint approximation [32]. To test the association, we adjusted our model for covariates including age, genderand genetic principal components (PC1-PC4), and...
We performed a bottom-up proteomics analysis of plasma, which had been depleted of the major blood proteins, using two-dimensional in-line liquid chromatography fractionation into ten fractions and label-free mass spectrometric analysis by QTOF MSE. The discovery cohort consisted of ten randomly selec...
Seventeen potentially secreted candidates (pCR = 1, pIR = 13 and 3 in both groups) were further investigated in two independent datasets (TCGA and GSE68204) confirming their over-expression in LARC and association with nCRT response (GSE68204). The expression of circulating amphiregulin ...
The aim of this paper is thus to identify both the common and unique transport components across the major Drosophila transporting epithelia, using both a hypothesis-led approach, based on already known transport processes, and a hypothesis-free approach, based on enriched expression in one or ...
Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling motor stage. We need objective biomarkers for early/pre-motor disease stages
as well as the more recently discovered strigolactone and karrikin receptors. In both cases we will detail how the components of the receptor-ligand interaction were identified with target biochemical and genetic approaches. Additionally, we highlight how better characterized systems paved the way for ...
Paper waspsget their name from the way they build their nests, which are made from their saliva and plant material and have a papery appearance. Because the nest looks somewhat like an umbrella, they are sometimes called umbrella wasps. They like to build their nests in protected areas of ho...
A schematic representation of the study design can be found in Figure 1. Fine mapping stage 1. SNPs were selected under the 1-LOD confidence interval of the previously defined linkage peak,9,11 using an empirical two-step strategy, in which candidate genes are prioritized using a bioinformatics...
5Human studies on the effect of traumatic stress have been constrained by the limited accessibility of the primary tissue type of interest (i.e., the human brain)6and by difficulties in prospectively capturing the effects of robust and relevant trauma exposures. To investigate the role of DNA ...