Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary and acquired
h2 represents SNP-based heritability in the observed scale. |r_g| represents the absolute value of the pairwise genetic correlation between PSC and the traits studied. MAF stands for a minor allele frequency. MHC region stands for the major histocompatibility complex region. The asterisk “*” i...
An overview of the microarray datasets included in the study is shown in Table 1. Table 1 Characteristics of the included microarray datasets. Full size table RRA integrated analysis Before RRA analysis, all included cohorts were standardized to reduce batch differences among multicenter data (...
Moreover, the muscle transcriptome shows a noticeable difference between beef and dairy cattle [26], the combined use of dairy and beef data may result in a bias. These eQTLs, specific to a certain muscle type or breed, would be lost. A similar problem can be seen in adipose tissue. ...
carotid artery (RCA) in transgenic mice following flow restriction for 21 days [Fig.5c]. The tissue specificity and recombination efficiency of the Tm-induced Cre activity was confirmed in bone-marrow smears and neuronal tissue fromS100β-eGFP-CreERT2-Rosa-26-tdTomatomice [data not shown]....
To date, the molecular mechanisms that underlie residual feed intake (RFI) in pigs are unknown. Results from different genome-wide association studies and gene expression analyses are not always consistent. The aim of this research was to use machine lea
The blue bars below represent the protein fragments encoded by the cDNA inserts contained in the corresponding phosphatidylinositide-binding clone. The gene exon structure is shown in green. Because the gene exon structures are interrupted by nonprotein coding intronic sequences, they do not ...
BMI1 of PRC1 has been shown to be involved in the maintenance and/or self-renewal of many types of stem cells, including embryonic, neural, hematopoietic, and prostate stem cells [48]. BMI1 promotes the proliferation of leukemic stem cells in a mouse model [49], and activates the self-...
(Supplementary Fig.8). A total of 605 enriched pathways had at least two differentially expressed genes, with heart-left ventricle being the tissue with the most significantly enriched pathways (n = 393). The rs6945340/HIP1variant showed the largest number of enriched pathways (n = ...
Full size image We obtained 20,688–42,725 candidate lncRNAs for the six vertebrate species (Fig. 1a and Extended Data Fig. 1e,f). Agreeing with previous reports20,24, these lncRNAs showed consistently lower protein-coding potential, lower expression level and higher tissue specificity than prot...