the early stage of the disease, and is characterized by the aberrant growth of cells in the cervix lining. It is primarily caused by Human Papillomavirus (HPV) infection, which spreads through sexual activity. This
brains to fine-map the critical cell types13,20, we replicated the critical cell type that was initially discovered, and were able to pinpoint the identity of the critical cell type more precisely during neurodevelopment to immature neurons and intermediate progenitor cells for the 16p11.2 locus....
structural methods, including cryo-electron tomography. Finally, we functionally validate LRP6 capsid interactions in vivo in mice, in the human BBB via primary cell culture, and beyond the BBB using human pluripotent stem cell (hPSC)-derived neurons. Understanding the mechanism of action of systemic...
Although previous studies show that microRNAs (miRNAs) can potentially be used as diagnostic markers for epilepsy, there are very few analyses of pediatric epilepsy patients. miRNA profiles using miRNA-seq was performed on plasma samples from 14 pediatri
divide asymmetrically, generating large numbers of neurons. Another important population of neural progenitors, known as intermediate progenitors or apical progenitors, are found in the subventricular zone (SVZ) [47,100,101,140]. Intermediate progenitors then continue to divide, making more neurons. ...
While excitatory neurons are the most numerous cell type within the cortex, several other vital cell types are also present. Fetal cortex at ages 15-23 p.c.w. contains, in decreasing order of proportion: exci- tatory neurons, inhibitory neurons that migrated from the ventral telencephalon, ...
Researchers have identified two types of neurons that enable the spinal cord to control skilled forelimb movement. The first is a group of excitatory interneurons that are needed to make accurate and precise movements; the second is a group of inhibitory
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The geneti...
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs a
The present invention provides a method for identifying an operational reaction pathway of a biosystem. The method includes (a) providing a set of systemic reaction pathways through a reaction network representing said biosystem; (b) providing a set of phenomenological reaction pathways of said biosyst...