The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular
experiments aimed at understanding the regulation of a key enzyme in fatty acid synthesis, acetyl-CoA carboxylase (ACC). Partially purified ACC was inactivated after incubation with ATP, which was attributed to phosphorylation by an unidentified kinase (Carlson and Kim1973). It was subsequently report...
In Stage 2, the user specifies an SEM in which gene expression is associated with the multivariate system of heritable phenotypes via regression or covariance relationships with components of the model. In our empirical application, the SEM consists of a general factor indexing genetic overlap across...
Upon infection, the pathogen spreads systemically from the root to the shoot and, consequently, fungal DNA and mycotoxins were detected in the basal part of the plant stem. Metabolite data revealed that the main pathway affected by Fusarium infections was “Fatty acids”, specifically the superclas...
an aspartic acid, and a histidine residue. This catalytic triad is buried inside the structure. The active site of these proteins is shielded by a lid, which, in the process of interfacial activation, opens up, granting access to the lipid substrate to interact with the active site [24,25...
Saccharomyces cerevisiae YFH7 is one of these P-loop proteins of unknown function. In this work we tried to integrate bioinformatics, structure, and enzymology to discover the function of YFH7. Sequence analysis revealed that yeast YFH7 is a yeast-specific protein showing weak similarity with the...
In contrast, hydrogen peroxide is more abundant in the differentiating peripheral zone, where it promotes stem cell differentiation [29]. Moreover, mutation of an ATP-dependent mitochondrial protease, AtFTSH4, caused increased oxidation of the SAM at high temperatures leading to altered mitochondrial ...
Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technolo
More and more patients receive various types of implants, such as catheters, valves, hips, that are all suitable substrates for these fungal cells to attach to and to form a biofilm. The extracellular matrix produced by biofilm cells is known to sequester antifungal drugs resulting in tolerance...
SERPINA1 encodes a serine protease inhibitor produced mainly in the liver. SERPINA1 mutations have been associated with familial intrahepatic cholestasis39, and SERPINA1 p.Glu366Lys with liver diseases40 and circulating liver enzymes41. We may have missed colocalizations where the true causal variants ...