To address this need, we first set out to generate a broad range of mouse models guided by the most commonly found genetic drivers of human HCC4. Human HCC is thought to evolve from a hepatocytic clonal origin under specific conditions promoting carcinogenesis, in contrast to recently described...
For the molecular docking process, we employed Glide-SP and Glide-XP software,31 integrated within the VirtualFlow Unity26 (VFU) pipeline (https://github.com/VirtualFlow/VFU). In the interest of scientific inclusivity, we provide a VFU setup that utilizes QuickVina50 and Smina,51 two open-...
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular
Deep vein thrombosis (DVT) is the formation of a blood clot in a deep vein. DVT can lead to a venous thromboembolism (VTE), the combined term for DVT and pulmonary embolism, a leading cause of death and disability worldwide. Despite the prevalence and as
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