In addition, FGF5 stimulates hypertrophic and partial cardiomyocytes to re-enter the mitotic phase of the cell cycle, which restores the function of hibernating myocardium following MI [53]. In contrast to the cardioprotective effects of FGF5, our MR results indicate that FGF5 is a risk factor ...
Cellular ras activity is required for passage through multiple points of the G0/G1 phase in BALB/c 3T3 cells. MicroinjectionexperimentsdemonstratedarequirementforcellularrasactivitylateinG1Inthisstudy,weusedtwoseparatemethodstoidentifyanadditionalrequirementforcell......
Optimal control theory is applied for the estimation of these time-varying effects. This methodology enables the authors to quantify the effects of a drug on each phase of the cycle. A compartmental model of the cell cycle with both constant and time varying parameters is presented. The ...
Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle. J. Med. Chem. 42, 3789–3799 (1999). Article CAS PubMed Google Scholar Fukuoka, K. et al. Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small ...
Taxol, a potent antitumor agent that binds b -tubulin and promotes microtubule assembly, results in mitotic arrest at the G 2 /M phase of the cell cycle. More recently, Taxol was shown to be a potent LPS mimetic in murine, but not in human macrophages, stimulating signaling pathways and ...
3g). CDKN2B encodes for the cyclin-dependent kinase inhibitor 2B, which controls the progression from G1 to S phase. Negative regulation of cell proliferation was the top pathway found among the depleted genes of the GOF screen (Extended Data Fig. 3b), supported by previous observations that...
Redox regulation is important in both the activation of proliferation and arrest of the cell cycle upon perception of environmental stress. Within this context, reactive oxygen species serve as ‘pro-life’ signals with positive roles in the regulation of the cell cycle and survival. However, very...
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression. The signal transducer and activator of transcription 3 (STAT3) is an IL-6-inducible transcription factor that mediates the hepatic acute phase response (AP... T Hou,S Ray,AR Brasier...
DNA methylation (n = 565), RNA sequencing (n = 185), and single-cell RNA sequencing data (n = 8 meningioma samples, n = 2 dura samples) of new samples reported in this manuscript have been deposited in the NCBI Gene Expression Omnibus under the accession GSE183656. Ad...
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