To address these limitations, we present a methodology based on automated formal reasoning, which permits the synthesis and analysis of the complete set of logical models consistent with experimental observations. We test hypotheses against all candidate models, and remove the need for simulation by ...
Derive the IS-LM model by considering the expectation into the model. You need to explain which factors affect each of the curve, and how the changes of these factors will shift the corresponding curv In regression analysis, the explanatory variables: A. are always...
Alternative splicing is crucial for cancer progression and can be targeted pharmacologically, yet identifying driver exons genome-wide remains challenging. We propose identifying such exons by associating statistically gene-level cancer dependencies from knockdown viability screens with splicing profiles and gen...
State the null and alternative hypotheses for the claim that the average age of community college students is 24.6 years. A university is interested in the average age of its students. A simple random sample of 30 students was se...
Molecular Autism (2020) 11:58 https://doi.org/10.1186/s13229-020-00360-3 REVIEW Open Access Cerebral organoids as tools to identify the developmental roots of autism Wai Kit Chan†, Rosie Griffiths†, David J. Price and John O. Mason* Abstract Some autism spectrum disorders (ASD) ...
University, University Park, State College, PA 16802, USA 5 Moderna, Inc., Cambridge, USA Abstract Background: Synonymous mutations, which change the DNA sequence but not the encoded protein sequence, can affect protein structure and function, mRNA matu- ration, and mRNA half...
Some autism spectrum disorders (ASD) likely arise as a result of abnormalities during early embryonic development of the brain. Studying human embryonic brain development directly is challenging, mainly due to ethical and practical constraints. However,
This paper proposes and then tests the utility of a relatively novel adaptation of finite mixture models, known as regression mixture models, as a potentially powerful alternative to examine differential effects of contexts. We propose a broad theoretical framework for more vigorous investigation of ...
In line with our hypotheses, we see that with easy access to a known declarative rule (in the Math, Area, Speed, and EV conditions) participants clear- ly relied on multiplicative integration based on Analysis(B). However, without such a rule and/or in more subjective do- mains (in the...
large, they will reject too many null hypotheses. From that, Benjamini and Hochberg's false discovery rate (FDR) may be a better choice. Likewise, many previous works49,50,51,52,53related the expression levels of each identified driver gene to prognostic value (e.g., the overall survival ...