Researchers have identified a potential new antiviral agent that is effective against common flu, rare Ebola virus, and a host of viruses in between, including HIV. The small molecule, named LJ001, targets lipids in enveloped viruses and prevents their entry into cells during the fusion process ...
Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions. Theranostics. 2021;11:27–47. Article PubMed PubMed Central CAS Google Scholar Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, Li S, Wang K, Wu X, Kang L, Yang C....
2a, b). Similarly, phenotypic signatures connected mlaA,C,D,E and F with an uncharacterized gene (ACX60_RS00705) encoding a protein with a Phenol_MetA_deg domain, which is part of a family of OM channel domains implicated in hydrophobic molecule uptake47,48 (r = 0.69–0.92, p ...
Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling motor stage. We need objective biomarkers for early/pre-motor disease stages to be able to intervene and slow the underly...
Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions. Theranostics. 2021;11:27–47. Article PubMed PubMed Central CAS Google Scholar Song Y, Wang Y, Zhang Y, Geng W, Liu W, Gao Y, Li S, Wang K, Wu X, Kang L, Yang C....
(Fig.8B and TableS2). The molecular functions and pathways of the high-risk group mainly focused on cell-molecule interactions, metabolic and uptake processes, and immune and inflammatory responses. BP terms for the low-risk group were related to keratinization, epidermal cell differentiation, and...
ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule inde- pendently of its catalytic activity. Cell Mol Life Sci. 2010;67(24):4213–32. 32. Kuno K, Bannai K, Hakozaki M, Matsushima K, Hirose K. The carboxyl- terminal half region of ADAMTS1 suppresses both tumorigenicity and ...
Identify the functional groups in the following molecule: Organic Chemistry: Organic chemistry is the branch of chemistry that deals with the structure, composition, reaction, and properties of hydrocarbons. As the name suggests hydrocarbons are carbon and hydrogen-containing compounds. Protein, carbohydra...
Previously, we showed that the small molecule forskolin and the transcription factor NEUROG2 could convert human skin fibroblasts into cholinergic neurons [8]. They could be further specified to become motor neurons by two additional transcription factors, ISL1 and LHX3, during the conversion process...
molecule activity conferring elasticity Muscle alpha-actinin binding Protease binding NADP binding Oxaloacetate decarboxylase activity Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity Biological process Synaptic vesicle endocytosis Small GTPase mediated signal transduction Cardiac muscle tissue ...