Ischemic heart disease is one of the leading causes of mortality worldwide, and thus calls for development of more effective therapeutic strategies. This study aimed to identify potential therapeutic targets for coronary heart disease (CHD) and myocardia
Cellular and viral FLIP proteins have several functions, including, most importantly, the inhibition of pro-apoptotic caspase 8 and modulation of NF-κB signaling. To investigate the essential role of cFLIP and its potential redundancy with vFLIP in PEL cells, we first performed rescue experiments ...
the central nodes, key interactions, and signaling pathways of DN were identified. To translate the findings to clinical application, a high-performance machine learning framework
5A and B). Loss of function of GmPHYA4 only moderately increased the epicotyl lengths in the WT (TL1) background and not in the gmphyA3 mutant background, suggesting a relatively weak role of GmPHYA4 in mediating FR light responses at the seedling stage. The gmphyA1A2 and gmphyA3A4 ...
Theobroma cacao L. cultivar Matina 1-6 belongs to the most cultivated cacao type. The availability of its genome sequence and methods for identifying genes responsible for important cacao traits will aid cacao researchers and breeders. We describe the se
Summary Drugs that produce DNA interstrand crosslinks (ICLs), between the two complementary strands of the double helix, have an important role in chemothe... Peter J McHugh and Victoria J Spanswick and John A Hartley - 《Lancet Oncology》 被引量: 431发表: 2001年 The DNA crosslink-induced...
Strikingly, the regulatory role of ZMP is conserved in bacteria, although the riboswitch mechanism involved is totally different (11). Although under physiological conditions ZMP is present in the micromolar range (7), upon feeding of the riboside precursor AICAR, ZMP concentration can increase to ...
Environmentally inflicted stresses such as salinity and drought limit the plant productivity both in natural and agricultural system. Increasing emphasis has been directed to molecular breeding strategies to enhance the intrinsic ability of plant to survive stress conditions. Functional screens in microorganis...
Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (l
the accuracy or integrity of any part of the work are appropriately investigated and resolved and the resolution documented in the literature. A.C. designed, performed and analyzed most of the experiments and bioinformatic analyses. S.T.M. extracted nucleic acids from all meningiomas, collected ...