The computer codes necessary for generating key results in this work have been deposited as in GitHub under https://github.com/wangzlab/COPD_multiomics. References Chronic obstructive pulmonary disease (COPD). World Health Organization http://www.who.int/respiratory/copd/en/ (2021). Lopez, A....
The current study performs a multivariate functional genomic analysis ofgto both leverage the shared power across seven cognitive traits for discovery and elucidate the biological pathways unique to, and shared across these traits. We specifically apply two multivariate methods. First, we introduce and ...
Global warming has greatly increased the impact of high temperatures on crops, resulting in reduced yields and increased mortality. This phenomenon is of significant importance to the rose flower industry because high-temperature stress leads to bud dorm
our colon becomes densely populated with microbes, in the range of 1011–1012cells/ml, the highest recorded density for any microbial habitat [2]. These microbes become an integral part of the digestive system breaking down complex molecules, modifying host-derived...
Syringa pinnatifolia Hemsl. is a shrub belonging to the Oleaceae family. The peeled woody stems and roots of S. pinnatifolia are used in Chinese traditional medicine. This plant has been used for centuries, and modern pharmacological research has reveale
phospholipase genes in two genotypes contrasting for rancidity across six key tissues during pearl millet growth revealed a predominant expression in grains, followed by seed coat and endosperm. Specifically, the genesPgPLD-alpha1-1,PgPLD-alpha1-5,PgPLD-delta1-7a,PgPLA1-II-1a, andPgPLD-...
antimalarial activity of one such product, Salinipostin A (SalA), to its ability to inhibit various serine hydrolases.1Serine hydrolases play key roles in lipid metabolism and in maintainingP. falciparum’s ability to remodel its plasma membrane throughout its life cycle in ...
The key structural features include ψ-loop (β1β2β3) nestling the α1 helix and a β′/β″ brace close to the N terminus of the domain. B, PASTA3 domain of PknB. The selenomethionine derivative of the L512M mutant was solved by molecular replacement with the PASTA4 model. ...
Cell membrane glycans contribute to immune recognition, signaling, and cellular adhesion and migration, and altered membrane glycosylation is a feature of cancer cells that contributes to cancer progression. The uptake and metabolism of glucose and other nutrients essential for glycan synthesis could under...
that explain smaller amounts of the overall variance, although this approach may sometimes result in loss of useful information45. When constructing biomarkers of aging, morbidity and frailty, PCA can be employed as a feature selection/compression method and may increase the robustness of predictive ...