Pigeons and certain other avian species produce a milk-like secretion in their crop sacs to nourish offspring, yet the detailed processes involved are not fully elucidated. This study investigated the crop sacs of 225-day-old unpaired non-lactating male pigeons (MN) and males initiating lactation...
A key feature of our method is that inferred enrichments automatically help identify new trait-associated genes. For example, accounting for enrichment in lipid transport genes yields strong evidence for association between MTTP and low-density lipoprotein levels, whereas conventional analyses of the ...
Paralleling the obesity epidemic, steatotic liver disease (SLD) is a growing burden worldwide. SLD includes a spectrum of conditions characterized by an excess of lipids, mainly triglycerides, stored in intracellular lipid droplets in the liver, potentially progressing to inflammation, fibrosis and ult...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome, which can lead to cirrhosis and liver cancer. While there is solid epid
Alterations in metabolism and bioenergetics are a hallmark of cancer, and adaptations in lipid metabolism are a prominent feature of prostate cancer.1,2 Seminal work has described the production of fatty acids through de novo lipogenesis as a defining feature of prostate cancer.3,4 More recently,...
However, the level of mRNA does not always correlate well with the level of protein, the key player in the cell (11, 12). It is thus insufficient to predict protein expression level from quantitative mRNA data. Proteome studies aim at the complete set of proteins encoded by the genome and...
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease (ILD) characterized by scarring of lung tissue, which progressively impairs lung function, eventually leading to respiratory failure and death [1]. Epidemiological data indicate that the incidence of IPF ranges from 0.09 to 1....
H Spatial feature plots showing co-localization of TNFα+ TAMs (left) and CD14 + monocytes (right) in spatial transcriptomic deconvolution analyses. The bone-containing area is within the red elliptical region Full size image Tumor-secreted IL34 induces high TNF expression in macrophages Our ...
phospholipase genes in two genotypes contrasting for rancidity across six key tissues during pearl millet growth revealed a predominant expression in grains, followed by seed coat and endosperm. Specifically, the genesPgPLD-alpha1-1,PgPLD-alpha1-5,PgPLD-delta1-7a,PgPLA1-II-1a, andPgPLD-...
Results Phenotypes and microscopic observations of SSP and TSP The most significant feature traditionally used to deter- mine the quality of medicinal S. pinnatifolia is the pres- ence of a dark-purple substance distributed within its stems (Fig. 1B, C). In addition, Safranin O ...