The RunPCA function was employed to conduct dimensionality reduction using principal component analysis. The ElbowPlot function establishes the appropriate principal components (PCs). The FindNeighbors function used utilized to construct a shared nearest neighbor graph for the top 30 PCs and clusters the...
The design of the study (ClinicalTrials.gov Identifier: NCT02876107, registered on August 22, 2016) is shown in Supplementary Fig.1. This is a randomized phase II trial to determine the pCR rate in patients with primary TN-IBC treated with PmAb, carboplatin, and paclitaxel followed by standa...
Valuable insights into the molecular mechanisms of complex disorders have been introduced using systems biology strategies, however, little progress has been made in the translation of this knowledge to the bedside. Although omics technologies, in line with advanced computational techniques, allowed the i...
In 1956, Brunswik proposed a definition of what he called intuitive and analytic cognitive processes, not in terms of verbally specified properties, but op
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is known to be linked with cancer evolution10,11. A cell may become the precursor of a subpopulation (clone) upon gaining a set of SNVs. Considerable heterogeneity exists not only between tumors but also within the same tumor12,13. Therefore, investigating the patterns of SNVs provides means...
The graph depicts the percentage of HIV-1MN replication on the right y-axis and the percentage of cell viability on the left y-axis, both plotted against the logarithmic scale of drug concentration. Each data point represents the mean ± standard error (SE) of six replicates in two ...