The top scoring gene in the module, PKN1 (protein-kinase-C-related kinase), controls processes such as regulation of the intermediate filaments of the actin cytoskeleton, tumor cell invasion, and cell migration57. It is activated by the Rho family of small G-proteins and might mediate the ...
Classic cadherin receptors cooperate with regulators of the to control tissue organization in health and disease. At the apical junctions of epithelial cells, the cadherin ring of the (ZA) couples with a contiguous ring of filaments to support morphogenetic processes such as tissue integration and ce...
The lifeact sequence, which attaches the fluorophore to actin filaments, was originally planned for the effector library used here. Because mCh fluorescence was merely used for estimating protein expression, we refer to this part of the construct as “P2A-mCh” for simplicity. Vectors and vector...
The lifeact sequence, which attaches the fluorophore to actin filaments, was originally planned for the effector library used here. Because mCh fluorescence was merely used for estimating protein expression, we refer to this part of the construct as “P2A-mCh” for simplicity. Vectors and vector...
CHIKV has a large number of cellular targets including epithelial cells, fibroblastic cells and primary immune cells which are susceptible to infection. Upon infection with the virus, these cells undergo significant modulation in some of their basic functions like innate immune response, apoptosis, au...
Here, we report autoantibody signatures across various grades of glioma serum samples and sub-categories of glioblastoma multiforme using Human Proteome chips containing ~17000 full-length human proteins. The deduced sets of classifier proteins helped to distinguish Grade II, III and IV samples from ...
The precise molecular mechanism of the conversion of a nontransmissible protein to the pathogenic prionoid form is not completely understood. Although the native, functionally-folded proteins possess important physiological functions, their misfolded amyloid aggregates are toxic to brain cells. The amyloid...