ActinJunctionsMorphogenesisOrganizationOrchestrateMaturationMutationsClassic cadherin receptors cooperate with regulators of the to control tissue organization in health and disease. At the apical junctions of
The top scoring gene in the module, PKN1 (protein-kinase-C-related kinase), controls processes such as regulation of the intermediate filaments of the actin cytoskeleton, tumor cell invasion, and cell migration57. It is activated by the Rho family of small G-proteins and might mediate the ...
The discoidal phagocytes have a disc-like or fried egg morphology with radial orientation of the actin filaments, whereas the polygonal phagocytes spread on glass into a polygon form with actin filaments aligned across the cell. In addition, medium phagocytes are intermediate in size (20–30 μ...
The lifeact sequence, which attaches the fluorophore to actin filaments, was originally planned for the effector library used here. Because mCh fluorescence was merely used for estimating protein expression, we refer to this part of the construct as “P2A-mCh” for simplicity. Vectors and vector...
no constriction structure is formed at the cell division site, but a specialized structure termed the phragmoplast, which consists of a bipolar array of microtubules and actin filaments, is assembled at the equator of a dividing cell, where the cell wall is finally built outward to the cell ...
Cells are enclosed by a selectively permeable membrane. Transport across this cellular membrane is an important characteristic of cells. The transport of nutrients or molecules across the cell membrane enables different physiological processes and cellular functions....
In contraction, the laterally projecting heads of the thick myosin myofilaments come in contact with the thin actin myofilaments and rotate on them. This pulls the thin myofilaments towards the middle of the sarcomere. The Z lines of the myofibril come closer together and the sarcom...
and miRNA involved in these processes. Cytoskeletal elements are required for spermatogenic cells to alter morphologically and translocate in the seminiferous tubule during spermatogenesis. Actin filaments are found in certain locations of spermatogenic cells and are controlled by various actin-binding protein...
(Supplementary Table 7) process networks like cell adhesion & cell matrix attractions and cytoskeleton remodelling involving actin filaments were enriched in this grade (Supplementary Table 8). Grade III Gliomas had pathways like cytoskeleton based cell adhesion and migration, cytoskeleton remodelling ...
Reorganization of actin filaments (9, 20, 21, 23) Cd2ap, Lad1, Limch1, Syne2, Synpo, Tmsb4x Depolymerization of filamentous actin (20, 21, 22) Carmil1 Microtubule-dependent AQP2 redistribution (89) Ino80, Kif16b, Mtus1, Syne2 Increased tight junction permeability (90) Ahnak, Cd2ap, Synp...