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The manner by which genetic diversity within a population generates individual phenotypes is a fundamental question of biology. To advance the understanding of the genotype–phenotype relationships towards the level of biochemical processes, we perform a proteome-wide association study (PWAS) of a comple...
Molecular Biology Plant Biology Introduction RpaB (“regulator of phycobilisome association B″) is an OmpR-type transcription factor of crucial importance for the transcriptional control of multiple photosynthesis-associated genes under varying light conditions. RpaB was discovered in the cyanobacterium Sy...
19, and primary biliary cirrhosis20(PBC) using multitrait analysis of GWAS21(MTAG). Although IBD is the umbrella term that includes CD and UC, we also surveyed the pairwise genetic correlation of PSC for CD and UC, respectively. We then performed functional fine-mapping analyses on the newly...
Homeobox transcription factors are involved in various aspects of plant development, including maintenance of the biosynthesis and signaling pathways of di... BQ Wen,MQ Xing,H Zhang,... - 《Journal of Integrative Plant Biology》 被引量: 0发表: 2011年 Rapid reversal of angiotensin I-induced cont...
The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/), a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae, has recently developed several new resources that allow the comparison and integration of information on a genome-wide scale, enab...
The flower gene has been previously linked to the elimination of slow dividing epithelial cells during development in a process known as "cell competition... MM Merino,C Rhiner,M Portela,... - 《Current Biology Cb》 被引量: 33发表: 2013年 Darwin...
Next, we compared the 3 subgroups (identified by 3378 most variable probes across tumours not methylated in normal adjacent pancreata) to identify differentially methylated sites across the entire genome and gain some potential insight into the biology that may differentiate the groups. We identified ...
processes and functions. Functional modules can be identified from the protein interaction networks derived from experimental data sets. However, these analyses are challenging because of the presence of unreliable interactions and the complex connectivity of the network. The integration...
BMC Systems Biology volume 1, Article number: 21 (2007) Cite this article 11k Accesses 22 Citations Metrics details Abstract Background Free fatty acids (FFA) and tumor necrosis factor alpha (TNF-α) have been implicated in the pathogenesis of many obesity-related metabolic disorders. When ...