PSMB9 gene encodes one of the catalytic subunits of proteasomes, which are involved in the metabolism of macromolecules related to proteasomes and may be involved in antigen processing and presentation, making PSMB9 an attractive target gene for cancer research. PSMB9 has been revealed to have ...
The widespread use of oxidative hair colouring cosmetics threatens public health. Phenylenediamine derivatives serve as the main pigment in permanent hair colours. They interact with biological macromolecules, altering their functional and structural physiology. The study aimed to investigate the effect of a...
8.Ganoderma lucidumpolysaccharides (GLPS) and triterpenoids are the main constituents ofGanoderma lucidum9, which have anti-tumor activating properties on macrophages, T lymphocytes, natural killer (NK) cells, dendritic cells, as well as initiating the production...
The widespread use of structure-based drug discovery techniques has proven instrumental in the search for small molecules that can specifically target macromolecules.29 The efficacy of molecular docking and free energy simulation methods is particularly noteworthy in assessing the binding strength between pr...
The exceptional mechanical properties of the shell are the result of interactions between eggshell minerals (calcium carbonate) and organic macromolecules (proteins, glycoproteins and proteoglycans), which comprise the organic matrix, a key factor required for shell calcification [7, 9, 34]. Although ...
A high throughput single-molecule method for identifying peptides and sequencing proteins based on nanopores could reduce costs and increase speeds of sequencing, allow the fabrication of portable home-diagnostic devices, and permit the characterization
Biomass building blocks are monomers of macromolecules required for the cellular function. The stoichiometric coefficients of the biomass building blocks satisfy the concentration of macromolecules in the cell (v, w, x, y, z). (B) Predicted growth upon single knockout of each gene in the blood...
(1998). Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules. J. Comput. Chem. 19, 319–333. 49. Tina, K.G., Bhadra, R., and Srinivasan, N. (2007). PIC: Protein interactions calculator. Nucleic Acids Res. 35, W473–W476. ...
ConSurf tool was used to predict the conserved functional regions or critically important sites in macromolecules based on the evolutionary dynamics of amino acid substitutions among homologs [28]. In this analysis, the conservancy of particular site was based on score which is in the range of 1...