One important application for aging clocks is to evaluate the impact of intervention strategies on BA. The CALERIE phase 2 randomized controlled trial was designed to test the effects of moderate (25%) calorie
the SARS-CoV-2 cell entry receptor, validating the phenotypic selection of the host factor screens.TMPRSS2was also highly enriched in our LOF screen, further confirming that SARS-CoV-2 infection of Calu-3 cells is dependent on the dominant SARS-CoV-2 S glycoprotein-priming mechanism in lung ...
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide1,2. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions. Tumour development is driven by the expansio...
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease (ILD) characterized by scarring of lung tissue, which progressively impairs lung function, eventually leading to respiratory failure and death [1]. Epidemiological data indicate that the incidence of IPF ranges from 0.09 to 1....
Motor disability is a critical impairment in stroke patients. Rehabilitation has a limited effect on recovery; but there is no medical therapy for post-stroke recovery. The biological mechanisms of rehabilitation in the brain remain unknown. Here, using
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Their chance of survival improves if they receive an injection of antivenom in time to counteract the sting’s effects. Habitat Scorpions live in very dry climates. Despite this, they are very sensitive to the loss of moisture from their body and hide during the day in shady locations. They...
The effects of the phospholipase D-antagonist 1-butanol on seedling development and microtubule organisa- tion in Arabidopsis. Plant Cell Physiol. 2003;44(7):687–96. 30. Li M, Hong Y, Wang X. Phospholipase D-and phosphatidic acid-mediated signaling in plants. Biochimica et Biophysica Acta...
(Additional file1: Figure S1). Therefore, to determine the effects of disrupting JunD expression in a highly invasive cell model, JunD knockdown was repeated in the two SW480-M6 lines. In both lines, decreased expression of JunD caused marked reductions in migration and invasion (Additional ...
The evaluation of the efficacy of immunotherapy is of great value for the clinical treatment of bladder cancer. Graph Neural Networks (GNNs), pathway analysis and multi-omics analysis have shown great potential in the field of cancer diagnosis and treatm