The characterization of protein-protein interactions (PPIs) is fundamental to the understanding of biochemical processes. Many methods have been established to identify and study direct PPIs; however, screening and investigating PPIs involving large or p
Secondary structure motifs and small protein domains can act as building blocks that are isolated and investigated to gain insights into protein global structure but can also modulate interactions with external partners. Most progress has been made in this field using synthetic peptides. Fragmentation ...
Coupled with fluorescence-activated cell sorting (FACS)1 (18, 20), yeast surface-displayed cDNA libraries potentially allow the selection of protein fragments or domains with affinity for any soluble molecule that can be fluorescently detected. In this report we demonstrate the utility of this ...
This is likely due to the aging process-associated accumulation of stresses that lead to protein aggregations and the dysregulations of signaling pathways, nucleocytoplasmic transports and epigenetics. Compared to non-neuronal cells or stem cell-derived neurons, aging-relevant and disease-associated human...
Update 1: according to this [Ref],1 k-means can be used to group items based on similar properties instead of relationships (nodes without the relationships between them). since I have a complete network topology, I think that K-means doesn't work in this scenario. Update 2...
The ankyrin repeat-containing protein with a suppressor of cytokine signaling box 2 (ASB2) gene that we initially identified as a retinoic acid-response gene in acute promyelocytic leukemia cells encodes the specificity subunit of an E3 ubiquitin ligase complex that is involved in hematopoietic cell...
DNA -> RNA -> protein Answer and Explanation:1 Become a Study.com member to unlock this answer!Create your account View this answer In cells, DNA contains all of the instructions required to make a vast array of structural and functional proteins. The process of transcription... ...
FLNA is a member of the actin-binding protein family that organizes actin filaments and is involved in numerous cellular processes, especially development. Many studies have reported the involvement of this protein in carcinogenesis. Using melanoma cell lines lacking or expressing FLNA, Fiori and colla...
Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs that were genetically linked to breast cancer through genome-wide association studies (GWAS). H
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