Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary and acquired
RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify. Here, we identify two RAS-binding Aff
A second limitation is that all large-scale GWASs have focused exclusively on BMD3,4,5. BMD is a clinically relevant predictor of osteoporotic fracture; however, it explains only part of the variance in bone strength12,13,14,15. Imaging modalities and bone biopsies can be used to collect d...
The availability of multiple whole genome sequences has facilitated in silico identification of fixed and polymorphic transposable elements (TE). Whereas polymorphic loci serve as makers for phylogenetic and forensic analysis, fixed species-specific tran
PMAIP1−/− mutants exhibit increased levels of P21 and FAS mRNA, which is absent in TP53−/− mutants. The y axis is relative expression is calculated by comparing the MAPT targeting sgRNA plus (+dox) or minus Cas9 expression (−dox). ∗p < 0.05, ∗∗p < 0.01, ∗...
Under the diffuse field approximation, the full-wave (FW) microtremor H/V spectral ratio (H/V) is modeled as the square root of the ratio of the sum of imaginary parts of the Green’s function of the horizontal components to that of the vertical one. For
Argonautes form tight complexes with small (19–31 nt) RNA partners and use them as guides to recognize target RNA molecules by Watson-Crick base pairing between the small and target RNAs (Meister, 2013). Argonaute proteins harbor an RNaseH-like Piwi domain that is capable of endonucleolytic...
Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. While a number of data-driven and experimental approaches have been suggested in the context of drug repurposing,
We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation with an antibody directed against tri-methylated lysine 4 of Histone H3, we demonstrate...
pbp1bA641C causing N214T change in PBP1b transglycosylase domain) that is associated with meningitis in an exploratory cohort of IPD patients (n = 2054, p = 6.8 × 10−6), in an independent confirmatory cohort (n = 2518, p = 2.3 × 10−6), and ...