outcomes from EHR data.We first consider the conditions in which machine learning may be especially useful with respect to two dimensions of a health outcome: 1) the characteristics of its diagnostic criteria, and 2) the format in which its diagnostic data are usually stored within EHR systems....
Our approach facilitates accurate identification of lupus nephritis in the EHR, enabling researchers to better understand patients’ SLE characteristics and serving as a foundation for lupus nephritis-related large cohort observational studies and clinical trials. We trained and evaluated the performance of...
Considering the structure and characteristics of missing values in a clinical dataset is essential for choosing the most appropriate data imputation technique, especially within conventional statistical methods. Accurately estimating missing values to reflect reality enhances the likelihood of obtaining high-qua...
Table 1. Characteristics of data sub-sets for study. Data SetSample Size (Visits)PurposeSelection Process Test 764 Final evaluation of Discriminative model Random from those with genetic data Validation 90 (originally 50) Discriminative model selection Random with oversampling from AHRQ criteria Developm...
Participant Characteristics and Summary of Homeless Shelter Use View LargeDownload Table 2. Comparison of Responses to Single-Item Screening Questions View LargeDownload Table 3. Performance of Single-Item Screening Questions in Identifying Future Homeless Shelter Use View LargeDownload Supplement. eTable...
Exposures Variables included demographics, cancer characteristics, comorbidities, laboratory values, imaging orders, and neighborhood variables. Main Outcomes and Measures The outcome estimated by machine learning models was likelihood of a delay greater than 60 days between cancer diagnosis and treatment init...
Table 1 Characteristics of ADNI and KADRC cohorts. Full size table We decided to use the common threshold for genome-wide significance (p < 5.0 × 10−8) instead of p < 3.42 × 10−10 (Bonferroni multiple test correction taking into account SNPs and phenotypes) becau...
Patient characteristics from Danish National CLL registry Based on the Danish National CLL registry, we identified 4149 patients diagnosed with CLL between January 2004 and July 2017. To ensure inclusion of all results from tests ordered at time of diagnosis we shifted time-point zero, which we re...
Baseline Characteristics and Model Input Variables for Patients Undergoing Procedure eTable 2. Thresholds and Sensitivity, Specificity, True and False Positives and Negatives, and F1 Score on Test Population for Both Models Supplement 2. Data Sharing Statement 1. Nepogodiev D, Martin J, Bicc...
29 contained information on TLR4 expression with clinical characteristics of interest, including demographics, histologic progression of dysplasia, polyp size, histology, initial CRC stage, tumor grade, metastasis, survival (overall [OS], disease specific [DSS], disease free [DFS]), recurrence, and ...