All 3000 genes with the most significant mutations identified by SCTransform were used to find anchor points through the FindIntegrationAnchors function. Based on these anchor points, we integrated the four samples using the IntegrateData function for subsequent analysis. The FindVariableFeatures function...
Aberrations in the capacity of DNA/chromatin modifiers and transcription factors to bind non-coding regions can lead to changes in gene regulation and impact disease phenotypes. However, identifying distal regulatory elements and connecting them with their target genes remains challenging. Here, we prese...
The survival of indigenous European wildcat (Felis silvestris silvestris) populations can be locally threatened by introgressive hybridization with free-ranging domestic cats. Identifying pure wildcats and investigating the ancestry of admixed individual
(1). In this context, CMR is being used as a broad term to describe the presence of various combinations of the traditional risk factors combined with features of themetabolic syndromethat contribute to global risk of CVD (2), as well as presence of clinical CVD itself. Excess body weight...
The identification of sequence positions displaying very high conservation of both structure and amino acid occupancy provided unambiguous anchors for the production of much more extensive sequence alignments. Popinga [64] performed this task through extensive use of HHpred [65] and MODELLER [66] to ...