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The belief that sensitivity measures of polarisation-modulated stimuli could offer a unique method for predicting macular damage arises from the fact that humans perceive polarised light solely because diattenuating macular structures convert it into a luminance signal. This mechanism guarantees that the r...
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Each nucle- otide change that caused a synonymous mutation was counted as 1 3 bp. For each patient, the number of total synonymous mutations across all synonymous positions were calcu- lated and the synonymous mutation rate was then calculated as Number of total synonymous mutations Synonymous ...
Pre-mRNA splicing is a key controller of human gene expression. Disturbances in splicing due to mutation lead to dysregulated protein expression and contribute to a substantial fraction of human disease. Several classes of splicing modulator compounds (S
(Fig.2M–O). Cells that are not adjacent to the lumen do not have a polarized expression of EZR; instead, it is observed in the cytosolic region throughout the cell. By e18.5, EZR expression is decreased throughout the anterior lobe.Ssr2encodes a component of the signal sequence ...
The ZO-1 intensity and cross sectional area were calculated from the cell shown entire image field using ImageJ. Nuclear counts per unit area were used to estimate cell density. Maximum intensity Z-projection of ZO-1 was divided by the number of cells. Three randomly chosen areas from three...
We selected 14 genes from this list to be confirmed by reverse transcriptase quantitative PCR (qPCR) in the C57BL6/J strain; selection criteria for qPCR confirmation included a robust fold change in expression (>2-fold change in expression) and a large relative signal intensity from the ...
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Product signal is plotted relative to substrate signal per lane. Data are mean ± s.d. from three biologically independent experiments. Extended Data Fig. 5 PARP1 trapping is the underlying cause of PARPi sensitivity in RNase H2-deficient cells This figure is related to Fig. 3a–c. a,...